IN VITRO SCREENING & EVALUATION OF CHEMICALS

体外筛选

• 批准号: 2879993
• 负责人: RICHARD J SAN
• 金额: $ 24.43万
• 依托单位: MAGENTA CORPORATION
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-30 至 2002-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2879993
• 关键词: Salmonella typhimurium; carcinogen testing; drug screening /evaluation; human tissue; laboratory mouse; lymphoma; mutagen testing; urine

The contractor shall test under Good Laboratory Practice approximately 20 - 25 NCI-supplied and coded samples per year for their ability to induce mutations in the mouse lymphoma assays. Up to 5 samples per year will not be coded samples of chemical compounds but will be human urine specimens (single or pooled specimens). The contractor shall also test under Good Laboratory Practices, approximately 20 - 25 NCI-supplied and coded samples per year for their ability to induce mutations in Salmonella Typhimurium. Up to 5 samples per year will not be coded samples of chemical compounds but will be human urine specimens (single or pooled specimens).

承包商应根据良好实验室规范进行大约测试 每年 20 - 25 个 NCI 提供和编码的样本，以证明其能够 在小鼠淋巴瘤试验中诱导突变。每年最多 5 个样品 不会是化合物的编码样本，而是人类尿液 标本（单个或混合标本）。 承包商还应测试 根据良好实验室规范，大约 20 - 25 个 NCI 提供和 每年对样本进行编码，以鉴定其诱导突变的能力 鼠伤寒沙门氏菌。 每年最多 5 个样品不会被编码 化合物样本，但将是人类尿液样本（单个 或混合样本）。