IN VITRO SCREENING & EVALUATION OF CHEMICALS

体外筛选

• 批准号: 6317837
• 负责人: RICHARD J SAN
• 金额: $ 26.5万
• 依托单位: MAGENTA CORPORATION
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-30 至 2002-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6317837
• 关键词: Salmonella typhimurium; carcinogen testing; drug screening /evaluation; human tissue; laboratory mouse; lymphoma; mutagen testing; urine

The contractor shall test under Good Laboratory Practice approximately 20 - 25 NCI-supplied and coded samples per year for their ability to induce mutations in the mouse lymphoma assays. Up to 5 samples per year will not be coded samples of chemical compounds but will be human urine specimens (single or pooled specimens). The contractor shall also test under Good Laboratory Practices, approximately 20 - 25 NCI-supplied and coded samples per year for their ability to induce mutations in Salmonella Typhimurium. Up to 5 samples per year will not be coded samples of chemical compounds but will be human urine specimens (single or pooled specimens).

承包商应在良好的实验室操作规范下进行大约 每年20-25个NCI提供的和编码的样本，以了解他们的能力 在小鼠淋巴瘤检测中诱导突变。每年最多5个样品 不会是化合物的编码样本，而是人类尿液 标本(单个或混合标本)。承包商还应测试 根据良好的实验室实践，大约20-25 NCI提供和 每年对样本进行编码，以了解它们诱导基因突变的能力 鼠伤寒沙门氏菌。每年最多5个样本将不会被编码 化合物样本，但将是人类尿液样本(单一 或汇集的标本)。

项目成果

Mutagenicity of chromium picolinate and its components in Salmonella typhimurium and L5178Y mouse lymphoma cells.

• DOI: 10.1016/j.fct.2005.05.003
• 发表时间: 2005-11
• 期刊: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
• 作者: P. Whittaker;R. San;J. Clarke;H. Seifried;V. Dunkel

Evaluation of commercial kava extracts and kavalactone standards for mutagenicity and toxicity using the mammalian cell gene mutation assay in L5178Y mouse lymphoma cells.

使用 L5178Y 小鼠淋巴瘤细胞中的哺乳动物细胞基因突变测定评估商业卡瓦提取物和卡瓦内酯标准品的致突变性和毒性。

• DOI: 10.1016/j.fct.2007.07.013
• 发表时间: 2008
• 期刊: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
• 作者: Whittaker,Paul;Clarke,JaneJ;San,RichardHC;Betz,JosephM;Seifried,HaroldE;deJager,LowriS;Dunkel,VirginiaC
• 通讯作者: Dunkel,VirginiaC