EFFICACY OF CHEMOPREVENTIVE AGENTS IN ANIMAL MODELS

将化学预防药物递送到肿瘤的靶部位的问题 以未代谢的高度浓缩的形式起作用是一个领域 显然需要更多关注的研究领域。在 在肺组织的情况下，药物递送的一个明确选择是 吸入含有化学预防剂的气雾剂。最近 布地奈德的雾化给药已经显示 显著抑制B[a]P诱导的肺腺瘤形成 品系A小鼠。 本工作说明的目的是研究 探讨预防肺癌的策略 化学预防剂的气雾剂递送。A/J小鼠肺 腺瘤模型应与B[a]P（一种高度普遍存在的 烟草烟雾中发现的环境致癌物，但主要是由于 化石燃料的燃烧。正在测试的代理人是一个5- 脂氧合酶抑制剂首先进行了一项范围确定研究 找到最大的无毒剂量这个剂量加上一个较低的剂量是 正在使用吸入给药进行测试。肺的频率 每只动物的腺瘤被用作本研究的终点。

The problem of delivering chemopreventive drugs to the target site of action in their unmetabolized, highly concentrated form is an area of research where clearly more attention needs to be focused. In the case of pulmonary tissue, one clear option for drug delivery is the inhalation of aerosols containing chemopreventive agents. Recently the aerosolized administration of budesonide has been shown to markedly inhibit B[a]P induced adenoma formation in lungs of the Strain A mouse. The objective of this workstatement is to investigate the mechanisms and efficacy and explore the strategy of preventing lung cancer by aerosol delivery of chemopreventive agents. The A/J mouse lung adenoma model shall be used with B[a]P, a highly ubiquitous environmental carcinogen found in tobacco smoke, but primarily due to the combustion of fossil fuels. The agent being tested is a 5- lipoxygenase inhibitor. A rangefinding study is first being conducted to find the highest nontoxic dose. This dose plus one lower dose are being tested using inhalation administration. The frequency of lung adenomas per animal is being used as the endpoint in this study.