SYNTHESIS OF CONGENERS & PRODRUGS

这个项目的具体目标是设计和合成 以下是： 1.具有确认活性的先导化合物的同系物，以增强 活力或效力。 2.具有结构修饰的前药，可提供改进的 药代动力学，改变药物传输，提高生物利用度 通过增加水的溶解度，或增加化学稳定性。 3.其他同时具有同类元素和元素的改变的结构 前药。引线的修饰也可以包括部分结构。 4.与天然产品有关的化合物，例如生物碱、 杂环、核苷、多肽。

The specific objectives of this project are to design and synthesize the following: 1. Congeners of lead compounds having confirmed activity, to enhance activity or potency. 2. Prodrugs with structural modifications that may provide improved pharmacokinetics, altered drug transport, improved bio-availability through increased water solubility, or increased chemical stability. 3. Other altered structures that possess elements of both congener and prodrug. Modifications of a lead may also include partial structures. 4. Compounds related to natural products, e.g., such as alkaloids, heterocycles, nucleosides, peptides.