SYNTHESIS OF CONGENERS & PRODRUGS

同系物的合成

• 批准号: 2852561
• 负责人: DAVID C. BAKER
• 金额: $ 21.58万
• 依托单位: UNIVERSITY OF TENNESSEE KNOXVILLE
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-09-30 至 2001-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2852561
• 关键词: alkaloids; drug design /synthesis /production; heterocyclic compounds; lead; nucleosides; peptides; prodrugs

The specific objectives of this project are to design and synthesize the following: 1. Congeners of lead compounds having confirmed activity, to enhance activity or potency. 2. Prodrugs with structural modifications that may provide improved pharmacokinetics, altered drug transport, improved bio-availability through increased water solubility, or increased chemical stability. 3. Other altered structures that possess elements of both congener and prodrug. Modifications of a lead may also include partial structures. 4. Compounds related to natural products, e.g., such as alkaloids, heterocycles, nucleosides, peptides.

本课题的具体目标是设计和综合