课题基金 / 基金详情

SYNTHESIS OF CONGENERS & PRODRUGS

SYNTHESIS OF CONGENERS & PRODRUGS
同系物的合成
批准号：
6316173
负责人：
DAVID C. BAKER
金额：
$0.0万
依托单位：
UNIVERSITY OF TENNESSEE KNOXVILLE
依托单位国家：
美国
项目类别：
财政年份：
1996
资助国家：
美国
项目状态：
已结题
起止时间：
1996-09-30 至 2000-03-31
来源：
https://reporter.nih.gov/project-details/6316173
关键词：
alkaloids drug design /synthesis /production heterocyclic compounds lead nucleosides peptides prodrugs

项目摘要

项目成果

DAVID C. BAKER的其他基金

相关文献

中文摘要
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英文摘要
The specific objectives of this project are to design and synthesize the following: 1. Congeners of lead compounds having confirmed activity, to enhance activity or potency. 2. Prodrugs with structural modifications that may provide improved pharmacokinetics, altered drug transport, improved bio-availability through increased water solubility, or increased chemical stability. 3. Other altered structures that possess elements of both congener and prodrug. Modifications of a lead may also include partial structures. 4. Compounds related to natural products, e.g., such as alkaloids, heterocycles, nucleosides, peptides.
期刊论文(1)
专著(0)
科研奖励(0)
会议论文
A chiral rhodium complex for rapid asymmetric transfer hydrogenation of imines with high enantioselectivity.
DOI： 10.1021/ol990098q
发表时间： 1999-08
期刊： Organic letters
影响因子： 5.2
作者： [Jianmin Mao;David C. Baker]
通讯作者： Jianmin Mao;David C. Baker
Tyoloindicines--Potent Antitumor Compounds
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Tyoloindicines--Potent Antitumor Compounds
ANTIMETASTATIC OLIGOSACCHARIDES FROM HYALURONIC ACID