MHC-BOUND SELF-PEPTIDES IN AUTOIMMUNE DISEASE

自身免疫性疾病中 MHC 结合的自肽

• 批准号: 2793778
• 负责人: Peter Johnson Wettstein
• 金额: $ 28.35万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-03-01 至 1999-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2793778
• 关键词: MHC class I antigen; MHC class II antigen; autoantigens; autoimmune disorder; genetically modified animals; high performance liquid chromatography; laboratory mouse; mass spectrometry; method development; murine encephalomyelitis virus; protein purification; protein sequence; simian virus 40; virus antigen

项目成果

Theiler's virus infection of genetically susceptible mice induces central nervous system-infiltrating CTLs with no apparent viral or major myelin antigenic specificity.

遗传易感小鼠的泰勒病毒感染会诱导中枢神经系统浸润 CTL，但没有明显的病毒或主要髓磷脂抗原特异性。

• 发表时间: 1998
• 期刊: Journal of immunology (Baltimore, Md. : 1950)
• 作者: Lin,X;Pease,LR;Murray,PD;Rodriguez,M
• 通讯作者: Rodriguez,M

Attacking HIV provirus: therapeutic strategies to disrupt persistent infection.

攻击艾滋病毒原病毒：破坏持续感染的治疗策略。

• DOI: 10.2174/187152606779025824
• 发表时间: 2006
• 期刊: Infectious disorders drug targets
• 作者: Margolis,DavidM;Archin,NancyM
• 通讯作者: Archin,NancyM

Sensitivity enhancement and second-dimensional information from solid phase extraction-capillary electrophoresis of entire high-performance liquid chromatography fractions.

整个高效液相色谱馏分的固相萃取毛细管电泳的灵敏度增强和二维信息。

• DOI: 10.1002/elps.1150160189
• 发表时间: 1995
• 期刊: Electrophoresis
• 影响因子: 2.9
• 作者: Strausbauch,MA;Madden,BJ;Wettstein,PJ;Landers,JP
• 通讯作者: Landers,JP

Interferon alpha/beta mediates early virus-induced expression of H-2D and H-2K in the central nervous system.

干扰素α/β介导病毒诱导的中枢神经系统中H-2D和H-2K的早期表达。

• 发表时间: 1997
• 期刊: Laboratory investigation; a journal of technical methods and pathology
• 作者: Njenga,MK;Pease,LR;Wettstein,P;Mak,T;Rodriguez,M
• 通讯作者: Rodriguez,M

Systematic development of on-line membrane preconcentration-capillary electrophoresis-mass spectrometry for the analysis of peptide mixtures.

系统开发用于分析肽混合物的在线膜预浓缩-毛细管电泳-质谱法。

• 发表时间: 1995
• 期刊: Journal of capillary electrophoresis
• 作者: Tomlinson,AJ;Naylor,S
• 通讯作者: Naylor,S