课题基金 / 基金详情

BIOLOGICAL ROLES OF NODAL RELATED GENES IN EMBRYOGENESIS

BIOLOGICAL ROLES OF NODAL RELATED GENES IN EMBRYOGENESIS
节点相关基因在胚胎发生中的生物学作用
批准号：
6019317
负责人：
Christopher V Wright
金额：
$22.46万
依托单位：
VANDERBILT UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
项目状态：
已结题
起止时间：
1997-07-01 至 2001-06-30
来源：
https://reporter.nih.gov/project-details/6019317
关键词：
Xenopus animal genetic material tag biological signal transduction developmental genetics embryogenesis gene expression genetic promoter element genetic regulation genetic regulatory element genetic transcription mesoderm nucleic acid sequence reporter genes transcription factor transforming growth factors vertebrate embryology

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英文摘要
DESCRIPTION (adapted from investigator's abstract): The goal of this application is to understand the roles in vertebrate development of the nodal and nodal-related genes, genes that encode secreted intercellular signaling proteins in the TGF-beta/BMP family. It is proposed to test the following hypotheses: (1) that Xnr1 and Xnr2 are essential for normal mesoderm induction and patterning in vivo; (2) that sinistral Xnr1 expression is a causative factor in the development of left-right morphological laterality in vertebrates, and (3) that the left-specific expression of Xnr1 is under transcriptional control via cis-acting Xnr1 gene sequences.
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