PDX-1 IN MAMMALIAN PANCREATIC DEVELOPMENT

PDX-1 在哺乳动物胰腺发育中的作用

基本信息

  • 批准号:
    6105437
  • 负责人:
  • 金额:
    $ 22.99万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    1999
  • 资助国家:
    美国
  • 起止时间:
    1999-07-01 至 2000-06-30
  • 项目状态:
    已结题

项目摘要

Description: (Directly taken from the application) The PDX-l gene (pancreas-duodenum homeobox gene - previously called X1Hbox8 in Xenopus (Wright et al., 1988), Idx-l or Stf-l in rat (Miller et al., 1994; Leonard et al., 1994), and Ipf-l in mouse (Ohlsson et al., 1994)) is expressed in the endoderm of frogs and mice in the developing rostral duodenum and pancreas. It is known that mice homozygous for a null mutation of the PDX- l gene have no pancreas and die as neonates. PDX-I thus joins the orphan homeobox gene spx, (previously called Hox-11; Roberts et al., 1994) being required for development of a specific organ. In mature murine pancreatic islets, PDX-I protein is specifically expressed in nuclei of beta cells. We have generated evidence that PDX-1 is part of the transcription factor complex activating insulin transcription, through the mutationally sensitive and evolutionarily conserved promoter sequence termed Flat-E. We propose a set of approaches to address the role of PDX-l in endodermal regional differentiation, the mechanism behind its region-specific activation in the pancreatic/duodenal area, and its role in islet cell ontogeny. We will assess the effects of mis-expressing PDX-1 in early developing lung epithelium and of sustaining its expression in acinar (exocrine) cells, in which it is not normally expressed. We will undertake a promoter analysis of the PDX-1 gene in vivo using reporter gene constructs in transgenic mice to find promoter/enhancer modules responsible for its normal expression pattern. Lastly, we will begin to address the role of PDX-1 in islet differentiation by examining the development of pancreatic tissue after cell type-specific gene excision using Cre-lox P system, and in chimeric PDX-1-/-/wild type animals.
描述:(直接取自申请书)pdx - 1基因

项目成果

期刊论文数量(0)
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Christopher V Wright其他文献

Christopher V Wright的其他文献

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{{ truncateString('Christopher V Wright', 18)}}的其他基金

Control of endocrine pancreatic beta-cell fate, function, and proliferation
控制内分泌胰腺 β 细胞的命运、功能和增殖
  • 批准号:
    10359799
  • 财政年份:
    2018
  • 资助金额:
    $ 22.99万
  • 项目类别:
Architecture and communication controlling the efficient generation of beta cells
控制β细胞有效生成的架构和通信
  • 批准号:
    8316317
  • 财政年份:
    2010
  • 资助金额:
    $ 22.99万
  • 项目类别:
Architecture and communication controlling the efficient generation of beta cells
控制β细胞有效生成的架构和通信
  • 批准号:
    8143507
  • 财政年份:
    2010
  • 资助金额:
    $ 22.99万
  • 项目类别:
Architecture and communication controlling the efficient generation of beta cells
控制β细胞有效生成的架构和通信
  • 批准号:
    8522280
  • 财政年份:
    2010
  • 资助金额:
    $ 22.99万
  • 项目类别:
Architecture and communication controlling the efficient generation of beta cells
控制β细胞有效生成的架构和通信
  • 批准号:
    8717653
  • 财政年份:
    2010
  • 资助金额:
    $ 22.99万
  • 项目类别:
Architecture and communication controlling the efficient generation of beta cells
控制β细胞有效生成的架构和通信
  • 批准号:
    7994960
  • 财政年份:
    2010
  • 资助金额:
    $ 22.99万
  • 项目类别:
Transcriptional networks of pancreas endocrine
胰腺内分泌转录网络
  • 批准号:
    7056496
  • 财政年份:
    2005
  • 资助金额:
    $ 22.99万
  • 项目类别:
PDX-1 IN MAMMALIAN PANCREATIC DEVELOPMENT
PDX-1 在哺乳动物胰腺发育中的作用
  • 批准号:
    6466603
  • 财政年份:
    2001
  • 资助金额:
    $ 22.99万
  • 项目类别:
CONTROL OF CORNEAL ENDOTHELIUM DEVELOPMENT IN THE MOUSE
小鼠角膜内皮发育的控制
  • 批准号:
    6530102
  • 财政年份:
    2000
  • 资助金额:
    $ 22.99万
  • 项目类别:
PDX-1 IN MAMMALIAN PANCREATIC DEVELOPMENT
PDX-1 在哺乳动物胰腺发育中的作用
  • 批准号:
    6352881
  • 财政年份:
    2000
  • 资助金额:
    $ 22.99万
  • 项目类别:

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