NORMAL METABOLISM AND ANATOMY OF BASAL FOREBRAIN IN MAN

描述（改编自申请人摘要）： 高分辨率共配准PET/MRI图像将用于开发 解剖学和图像处理方法来研究基底前脑。 70名经过严格筛选的健康成年人（每十年5名男性和5名女性 年龄在20-90岁之间）在进行一系列语言学习任务时进行成像。 将对另外30名个体进行成像，以增加统计功效。 用GE 2048头部专用扫描仪（4.5 mm分辨率）进行扫描 在平面上，2.5-3.5M计数），使用18F-脱氧葡萄糖作为示踪剂。 冠状 MRI图像（1.2mm厚切片）与PET图像配准。 的 研究者将重点关注纹状体、苍白球和无名质， 特别注意腹侧纹状体（纹状体核，纹状体 桥进入无名质）和腹侧苍白球，因为它们 较少研究（相对于背尾状核和壳核）与MRI 一种新的3D地标变形方法，薄板样条，将对齐 并将所有图像调整到相同的坐标。 研究人员将开发 基底前脑解剖标志和方差图像的图谱， 将目标对准统一坐标。 他将检验 与年龄相关的萎缩和代谢减少， 运动皮质（后壳核、背壳核和苍白球） 与边缘系统相连（例如，腹侧纹状体和苍白球）。 他将 扩展当前的相关方法，以了解地形 额基底前脑连接，并评估之间的相似性 已知非人类灵长类动物地形和人类代谢相关模式。 基底前脑之间的相互代偿大小关系 背侧纹状体（壳核到苍白球）和腹侧纹状体（ （腹侧苍白球核）系统将被探索，以测试 假设纹状体面积较小的个体表现出更大的 这些区域发送到的结构中的大小或功能活动 抑制性投射 最后，研究人员将测试现实 基底前脑的幻影，以提供准确的经验措施， PET分辨率和检查冠状位死后甲酚紫和 Weigert染色的脑切片，以显示冠状切片位置坐标 并评估它们的变化。

DESCRIPTION (Adapted from applicant's abstract): A large data set of high-resolution coregistered PET/MRI images will be used to develop anatomical and image-processing methods to study the basal forebrain. Seventy rigorously screened healthy adults (5 men and 5 women in each decade from ages 20-90) were imaged while performing a serial verbal learning task. Thirty additional individuals will be imaged to increase statistical power. Scans were obtained with a GE 2048 head-dedicated scanner (4.5-mm resolution in plane, 2.5-3.5M counts) using 18F-deoxyglucose as the tracer. Coronal MRI images (1.2mm thick slices) were coregistered to the PET images. The investigator will focus on the striatum, pallidum and substantia innominata, with special attention to the ventral striatum (nucleus accumbens, striatal bridges into the substantia innominata) and ventral pallidum because they have been less studied (relative to the dorsal caudate and putamen) with MRI in man. A new 3D landmark-morphing method, thin-plate splines, will align and size all images to the same coordinates. The investigator will develop an atlas of basal forebrain anatomical landmarks and variance images for aligning subjects to uniform coordinates. He will test the hypothesis of greater age-related shrinkage and metabolic decrease in areas linked to motor cortex (posterior and dorsal putamen and globus pallidus) than areas linked to the limbic system (e.g., ventral striatum and pallidum). He will extend current correlational methods for understanding the topography of frontal-basal forebrain connectivity and evaluate the similarities between known nonhuman primate topography and human metabolic correlational pattern. Reciprocal compensatory size relationships between basal forebrain structures in the dorsal striatal (putamen to globus pallidus) and ventral (nucleus accumbens to ventral pallidum) systems will be explored to test the hypothesis that individuals with smaller striatal areas will show greater size or functional activity in the structures to which these areas send inhibitory projections. Lastly, the investigator will test realistic phantoms of the basal forebrain to provide accurate empirical measures of PET resolution and examine coronal postmortem cresyl violet and Weigert-stained brain slices to develop coronal slice location coordinates and assess their variation.