FUNCTION AND NEURONAL MECHANISMS OF INTERVAL TIMING

在过去的几年里，许多经验和理论上的努力 我致力于理解间隔时间的意义，处理 在动物中，以秒为量级的持续时间。连贯的理论 对时间处理的中心组件的描述已经被 详细阐述，包括各种动物学习和 心理物理学范式。最近，这些范例中的许多都是 与人类一起研究，证实了我们账户的主要特征。这和 Meck的同伴建议，扩展了对人类和 动物计时。本提案专门讨论下列范例： 正常人群和患有精神障碍的患者人群 基底节表现为异常的颞叶加工。失调症 基底节干扰时间加工的某些成分 系统，并提供了不同类型的功能障碍的概况 与不同结构的神经损伤有关。这项建议 在实验中将这些患者群体与标准数据进行对比 旨在揭示颞叶认知障碍的不同组成部分 纹状体皮质中与明显神经损伤相关的加工 网络。我们研究了两大类认知功能障碍：一 涉及记忆存储和/或取回时间的失真 信息，以及另一种特定于同时加工的时间 信息。前者对多巴胺能调节敏感，而 后者与纹状体结构的损伤有关。

Over the past several years, much empirical and theoretical effort has been devoted to understanding the interval time sense, processing of durations of the order of seconds, in animals. A coherent theoretical description of the central components of temporal processing has been elaborated, encompassing a wide variety of animal learning and psychophysics paradigms. More recently many of these paradigms have been studied with humans, confirming central features of our account. This and the companion proposal from Meck, extends this parallel study of human and animal timing. The present proposal is devoted to these paradigms in normative human populations and in patient populations with disorders of the basal ganglia showing aberrant temporal processing. Disorders of the basal ganglia interfere with certain components of temporal processing systems and present a profile of different kinds of dysfunctions associated with neural damage to different structures. This proposal contrasts these patient populations with normative data in experiments designed to reveal distinct components of cognitive impairment in temporal processing associated with distinct neural damage in striato-cortical networks. Two major classes of cognitive dysfunction are studied: one involving distortions in memory storage and/or retrieval of temporal information, and another specific to simultaneous processing of temporal information. The former is sensitive to dopaminergic regulation and the latter is associated with damage to structures in the striatum.