SIESTA NAPS IN OLDER PEOPLE

描述（改编自申请人摘要）：本研究是一项新的 关于行为干预的建议，即采取 午睡，这可能会减轻一些睡眠和警觉性障碍 许多年长的男人和女人都经历过。 这个实验的主要目的 是为了确定老年人（70岁以上），每天提前90分钟 下午“午睡”方案，适用于2周，在家里， 3天在实验室，将有助于促进夜间警觉性和预防 不希望的早睡（UEES）可能会在晚上表现出来 嗜睡和/或高级睡眠阶段综合征（ASPS）症状。 一 将采用受试者内设计，所有受试者均同时进行 条件下，一半的受试者先做“午睡”条件，一半的受试者先做“午睡”条件。 “不打瞌睡”的条件第一。 两者之间相隔18天 条件 申请人将研究健康对照组和睡眠 抱怨UEES症状的疾病患者，期待干预 对患者群体最有利。 家庭措施将 包括警觉性的主观评级，睡眠（和午睡）日记，社会 节律测量（SRM）和Actillume测量手腕活动和光 水平 实验室测量还将包括直肠温度， 多导睡眠图测量午睡和睡眠，以及单次脑电图和清醒脑电图 夜间睡眠的测量。 对于患者（10 m，10 f）和对照组 (10m，10 f）组，申请人将测试午睡 午睡方案，在家里实施14天，在 实验室，将有效果：1）延迟自我选择的就寝时间 和/或消除晚上小睡，2）改善手动操作时的晚上表现， 灵活性、系列反应、反应抑制和单调视觉 提高夜间主观警觉性（自评） 和减少客观的夜间嗜睡（Mackay试验，清醒EEG 分析），4）改变曝光模式和5）增加 生活方式的规律性。 干预是从Borbely的 人类昼夜节律系统的原始“过程S/过程C”模型，以及 此外，还将使用实验室睡眠和昼夜节律测量， 研究模型的机制，并评估任何后果 午睡是根据昼夜节律和夜间睡眠进行的。 结果 从实验中将揭示潜在的好处（和成本）， 人们的生活方式，包括一个早期的下午午睡， 确定健康老年人和抱怨老年人之间的差异 与不必要的傍晚嗜睡有关的症状。

DESCRIPTION (Adapted from applicant's abstract): This study is a new proposal concerned with a behavioral intervention, that of taking an afternoon nap, which might lessen some of the sleep and alertness disorders experienced by many older men and women. The major aim of this experiment is to determine whether for older people (70y+), a daily 90-minute early afternoon "siesta nap" regimen, applied for 2 weeks in the home followed by 3 days in the laboratory, will help promote evening alertness and prevent Unwanted Early Evening Sleepiness (UEES) which may be manifest as evening napping and/or Advanced Sleep Phase Syndrome (ASPS) symptoms. A within-subject design will be employed with all subjects doing both conditions, half of the subjects doing the 'nap' condition first, half the 'no-nap' condition first. Eighteen days will intervene between the two conditions. The applicants will study both healthy controls and sleep disorders patients who complain of UEES symptoms, expecting the intervention to be most beneficial for the patient group. Home-based measures will include subjective ratings of alertness, sleep (and nap) diaries, the Social Rhythm Metric (SRM), and Actillume measures of wrist activity and light level. Laboratory measures will additionally include rectal temperature, polysomnographic measures of naps and sleeps, and single MSLT and waking EEG evening measures of sleepiness. For both patient (10m, 10f) and control (10m, 10f) groups, the applicants will test the hypothesis that the siesta nap regimen, imposed for 14 days at home and for three days in the laboratory, will have the effect of: 1) delaying the self selected bedtime and/or eliminating evening naps, 2) improving evening performance at manual dexterity, serial response, response inhibition and monotonous visual vigilance tasks, 3) increasing evening subjective alertness (self- rated) and decreasing objective evening sleepiness (MSLT trial, waking EEG analysis), 4) changing the pattern of light exposure and 5) increasing the level of lifestyle regularity. The intervention is derived from Borbely's original "Process S/Process C" model of the human circadian system, and laboratory sleep and circadian measures will be used additionally to investigate the mechanisms of the model, and to evaluate any consequences of the siesta naps on circadian rhythm timing and nocturnal sleep. Results from the experiment will reveal the potential benefits (and costs) to older people of a lifestyle that incorporates an early afternoon nap, and determine how these vary between healthy seniors and those complaining of symptoms related to unwanted early evening sleepiness.