Aging Well, Sleeping Efficiently

描述（由申请人提供）：本申请是计划项目资助POI AG 020677（“老化良好，睡眠有效”）的06年至10年竞争性更新的修订版（A1）。老年人的失眠是一种广泛流行的健康状况，与严重的痛苦，功能障碍，医疗保健利用率增加和高财务成本有关。该计划的目的是确定新的生理，电生理，遗传和功能神经解剖学相关的老年人失眠。所有项目都将使用失眠认知行为治疗（CBTI）作为“干预挑战”，以确定失眠症状的变化如何影响失眠的这些相关因素。该计划有四个相互关联的项目和三个核心，检查一组120名老年人与inflammation（OAI）都接受CBTI，以及人口统计学上平衡的100名良好睡眠者（GS）。所有参与者均为60岁以上;将对男女进行研究。项目1-3将分别检查参与者的一个子集。参与者招募广告将由核心A（管理-僧侣）提供。所有受试者将被招募、电话预筛选、同意筛选并使用核心B（临床核心- Buysse/Germain）资源进行筛选，然后使用核心C（数据管理和统计- Mazumdar/Hall）提供的程序分配至三个不同项目之一。所有参与者都将为项目4（遗传学-尼姆冈）做出贡献。核心B还将负责提供CBTI并收集临床变量。核心A将提供一般行政管理;核心C将处理数据分析和统计。项目1（昼夜节律/稳态- Monk/Buysse）将涉及使用睡眠剥夺挑战对昼夜节律和睡眠稳态的实验室评估;项目2（过度觉醒- Hall）将使用一系列实验室挑战来评估心理-生理觉醒的动态特性;项目3（PET成像- Nofzinger）将涉及NREM睡眠和觉醒期间的PET成像。项目4（Genetics-Nimgaonkar）将检查Per 3基因的多态性和功能特性，检查这些多态性与行为和生理变量之间的相关性。所有四个组成项目基本上都有两个主要目标：1）在他们感兴趣的特定领域内调查老年人失眠的基线相关性; 2）确定这些相关性是否也与失眠的非药物治疗（CBTI）的成功水平有关。这个项目将大大促进我们对老年人失眠及其治疗的理解。

DESCRIPTION (provided by applicant): This application is a revised version (A1) of a competing renewal for years 06 through 10 of program project grant POI AG020677 ("Aging Well, Sleeping Efficiently"). Insomnia in older adults is a widely prevalent health condition that is associated with significant distress, functional impairment, increased utilization of healthcare, and high financial costs. The aim of the program is to identify novel physiological, electrophysiological, genetic and functional neuroanatomical correlates of insomnia in older adults. All projects will use treatment with Cognitive Behavioral Treatment of Insomnia (CBTI), as an "intervention challenge" to determine how changes in insomnia symptoms affect these correlates of insomnia. The program has four inter-related projects and three cores examining a group of 120 Older Adults with Insomnia (OAI) all receiving CBTI, as well as a demographically balanced group of 100 good sleepers (GS). All participants will be 60y+; both genders will be studied. Projects 1-3 will each examine a subset of the participants. Advertising for participant recruitment will be provided by Core A {Administration - Monk). All participants will be recruited, telephone pre-screened, consented for screening and screened using Core B (Clinical core - Buysse/Germain) resources, and then assigned to one of three different projects using procedures provided by Core C {Data Management and Statistics - Mazumdar/Hall). All participants will contribute to Project 4 {Genetics - Nimgaonl<at). Core B will also be responsible for delivering the CBTI and collecting clinical variables. Core A will provide general administration; Core C will handle data analysis and statistics. Project 1 {Circadian/homeostatic - Monk/Buysse) will involve a laboratory evaluation of circadian rhythms and sleep homeostasis using a sleep deprivation challenge; Project 2 {Hyperarousal - Hall) will use a series of laboratory challenges to evaluate the dynamic properties of psycho-physiological arousal; Project 3 {PET imaging - Nofzinger) will involve PET imaging during NREM sleep and wakefulness. Project 4 {Genetics-Nimgaonkar) will examine polymorphisms and functional properties of the Per3 gene, examining correlations between these polymorphisms and behavioral and physiologic variables. All four of the component projects essentially have two major aims: 1) to investigate baseline correlates of insomnia in older adults within their particular domain of interest; and 2) to determine whether these correlates also relate to the level of success of a non-pharmacological treatment for insomnia (CBTI). This Program Project will significantly advance our understanding of insomnia and its treatment in older adults.