FUNCTION OF GLUTAMATE RECEPTORS IN VISUAL CORTEX

视觉皮层谷氨酸受体的功能

• 批准号: 2888499
• 负责人: NIGEL W DAW
• 金额: $ 19.44万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-05-01 至 2000-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2888499
• 关键词: action potentials; age difference; brain mapping; calcium flux; cell type; developmental neurobiology; electrophysiology; glutamate receptor; laboratory rat; neural plasticity; neurophysiology; phosphatidylinositols; receptor expression; visual cortex

DESCRIPTION: A variety of experiments suggest that metabotropic glutamate receptors are important in sensory-dependent plasticity in the visual cortex. At the same time, metabotropic glutamate receptors have a variety of effects on the electrophysiological properties of cells in the visual cortex, and these have not been extensively studied. Presynaptic inhibition, postsynaptic excitation, and potentiation of the response to NMDA have all been shown to occur, but each has been studied in one layer of the cortex and not in others. Most likely these different effects occur because there are a variety of metabotropic glutamate receptors (defined by molecular biological techniques) located at different places in the cortex. Work with in situ hybridization, and with antibodies created against particular metabotropic glutamate receptors (defined by molecular biological techniques) located at different places in the cortex. Work with in situ hybridization, and with antibodies created against particular metabotropic glutamate receptors, shows that there are laminar differences in the distribution of these receptors, and these change with age. This application proposes to study the laminar differences and development of the electrophysiological effects of metabotropic glutamate receptors. The hypothesis is that these electrophysiological properties make it more likely that the postsynaptic cell will fire when the presynaptic cell fires at particular ages in development, leading to strengthening of synapses through a Hebbian mechanism, which may correlate with the critical period for sensory-dependent plasticity.

描述：各种实验表明，代谢型谷氨酸 感受器在视觉的感觉依赖可塑性中是重要的 皮层同时，代谢型谷氨酸受体具有 对细胞电生理特性的各种影响， 视觉皮层，这些还没有被广泛研究。 突触前抑制、突触后兴奋和增强 对NMDA的反应都被证明会发生，但每一种都被研究过。 在皮层的一层而不是其他层。很可能这些 不同的影响发生，因为有各种代谢 谷氨酸受体（由分子生物学技术定义）位于 在大脑皮层的不同地方。使用原位杂交技术， 用针对特定代谢型谷氨酸的抗体 受体（由分子生物学技术定义）位于 大脑皮层的不同位置。使用原位杂交技术， 用针对特定代谢型谷氨酸的抗体 受体，表明在分布中存在层状差异 随着年龄的增长而变化。本申请 建议研究层流的差异和发展， 代谢型谷氨酸受体的电生理作用。的 假设是这些电生理特性使其更 突触后细胞可能会在突触前细胞 火灾在特定年龄的发展，导致加强 突触通过Hebbian机制，这可能与 感觉依赖可塑性的关键时期。