NUTRITION, GENES AND HIP FRACTURE RISK IN UTAH

描述：（改编自研究者摘要）研究者 提出一个基于人群的病例对照研究， 犹他州髋部骨折病因中的营养和遗传因素 50岁或以上的居民。 他们将招募950名女性和950名男性 从所有髋部骨折的随机样本中， 犹他州居民在1997年至2000年期间和同等数量的性别和年龄匹配的 对照 将检验以下假设。 1. 摄入量低 蛋白质与髋部骨折风险增加有关;分析将 扩展到包括蛋白质摄入量和赖氨酸的来源和质量 摄入 分析中的协变量将包括总能量、脂质 碳水化合物钙和维生素D 2. 候选基因的等位基因变体 与骨质疏松症相关的标志物增加髋部骨折的风险。 他们将研究与骨形成和重塑有关的基因， 包括COL 1A 1和COL 1A 2，它们是编码1型胶原蛋白链的基因， 前胶原、维生素D受体、骨钙素、骨粘连蛋白和 骨桥蛋白。 目的是评估髋部骨折的风险归因于 这些候选基因在一个代表性的人类背景下， 人口 3. 上述候选基因和营养素相互作用， 增加或倍增，以增加髋部骨折的风险。 具有骨质疏松症高危等位基因的个体可能更易受影响 与营养和其他环境因素有关。 美洲原住民髋部骨折的初步研究（50例，100 控制）将制定适当的方法，包括膳食评估。 美洲原住民的骨折还没有得到充分研究， 包括骨密度、饮食、 习惯、生活习惯、环境暴露和遗传特征。 的 研究人员指出，提出的多学科方法可能导致 有效的公共卫生干预措施，以减少髋部骨折的负担。

DESCRIPTION: (Adapted from Investigator's Abstract) The investigators propose a population-based case-control study of the role of novel nutritional and genetic factors in the etiology of hip fractures in Utah residents, ages 50 years or older. They will recruit 950 women and 950 men with incident hip fractures from a random sample of all hip fractures among Utah residents during 1997-00 and an equal number of sex- and age-matched controls. The following hypotheses will be tested. 1. Low intake of protein is associated with an increased risk of hip fracture; analyses will be extended to include source and quality of protein intake and lysine intake. Covariates in analyses will include intakes of total energy, lipid, carbohydrate, calcium, and vitamin D. 2. Allelic variants of candidate gene markers associated with osteoporosis increase the risk of hip fracture. They will study genes that are involved in bone formation and remodeling, including COL1A1 and COL1A2, the genes that encode the chains of type 1 procollagen, the vitamin D receptor, osteocalcin, osteonectin, and osteopontin. The goal is to evaluate the risk of hip fracture attributable to these candidate genes within the context of a representative human population. 3. The candidate genes and nutrients mentioned above interact, additively or multiplicatively, to increase the risk of hip fracture. Individuals with high-risk alleles for osteoporosis may be more susceptible to nutritional and other environmental causes of hip fracture. A pilot study of hip fractures among Native Americans (50 cases, 100 controls) will develop appropriate methods, including dietary assessment. Fractures among Native Americans are understudied and this minority group includes subgroups with considerable variation in bone density, dietary habits, lifestyle habits, environmental exposures, and genetic traits. The investigators state that the multidisciplinary approach proposed may lead to effective public health interventions to reduce the burden of hip fractures.