THE CACHE COUNTY FAMILY BASED COHORT STUDY ON AGING

描述：（申请摘要）犹他州该高速缓存县，研究 老年记忆是一项关于痴呆和认知能力下降的纵向研究， 非常适合发展遗传学的纵向流行病学研究， 和环境决定因素的年龄指定的生存特征， 变化率特征 我们提出以下具体目标， 该高速缓存县老龄化家庭队列研究： 1. 来自原始5092缓存队列成员的数据将链接到 犹他州人口数据库的计算机化家谱记录。 的 将分析每个队列成员的家庭结构，并将变量 根据每个参与者的平均家族寿命和家族晚期寿命得出 女性生育能力 我们将研究家族长寿与 以及女性生育能力和年龄特征。 2. 将重新联系估计4100名存活的队列成员， 访谈，以收集有关其健康史和生命状态的数据， 他们亲属的联系方式。将采集血样， 加工，并储存用于未来的遗传，营养和生物标志物研究。 3. 目标2中确定的亲属数据，包括估计11 000人 存活的兄弟姐妹，将链接到原始队列的系谱数据库 成员使用犹他州人口数据库。 在试点研究中，我们将选择 一个随机抽样的生活在卡什县以外的兄弟姐妹， 招募400人进行数据收集，以确定可行性 全面的以家庭为基础的协会研究， 和犹他州以外的地方 4. 将开发新的统计工具， 家庭关联研究中的特征。 我们建议扩大统一的 在三个新的领域为以家庭为基础的关联研究建立模型的战略： a）在缺乏亲本基因型数据的研究中的应用; B） 表型干扰均值处理问题的解决 分布;和c）将表型视为删失生存期 结果。我们将研究统一建模方法的使用--在 sib-pair框架--测试候选基因之间的关联程度 和年龄特定的性状，并测试基因-基因和基因-环境 交互.

DESCRIPTION: (Abstract from application) The Cache County, Utah, Study on Memory in Aging, a longitudinal study of dementia and cognitive decline, is well-suited for development of longitudinal epidemiologic studies of genetic and environmental determinants of age-specified survival traits and rate-of-change traits. We propose the following specific aims to establish the Cache County Family-based Cohort Study on Aging: 1. Data from the original 5092 Cache cohort members will be linked to the computerized genealogical records of the Utah Population Data Base. The family structure of each cohort member will be analyzed and variables will be derived for each participant's average familial longevity and familial late female fertility. We will examine the associations between familial longevity and late female fertility and age-specified traits. 2. The estimated 4100 surviving cohort members will be re-contacted and interviewed to collect data on their health history and the vital status and contact information for their relatives. Blood samples will be obtained, processed, and banked for future genetic, nutritional, and biomarker studies. 3. Data on the relatives ascertained in Aim 2, including an estimated 11,000 living siblings, will be linked to the pedigree database of original cohort members using the Utah Population Data Base. In a pilot study we will select a random sample of the living siblings living outside of Cache County and recruit 400 of them for data collection in order to determine the feasibility of full-scale family-based association studies that extend beyond Cache County and beyond Utah. 4. New statistical tools will be developed for the study of age-specified traits in family-based association studies. We propose to extend the unified modeling strategies for family-based association studies in three new areas: a) application in studies with the absence of parental genotype data; b) solution of the problem of handling the nuisance mean of phenotypic distributions; and c) consideration of phenotype as a censored survival outcome. We will investigate use of the unified modeling approach--within the sib-pair framework--to test the degree of association between candidate genes and age-specified traits and to test for gene-gene and gene-environment interactions.