AUGMENTATION OF TRABECULAR BONE BY LOW MAGNITUDE STRAIN
通过低强度应变增强骨小梁
基本信息
- 批准号:2837553
- 负责人:
- 金额:$ 27.19万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1996
- 资助国家:美国
- 起止时间:1996-12-01 至 2000-11-30
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Preliminary work in this laboratory has demonstrated that extremely low
magnitude (<30 Microstrain) mechanical signals can be osteogenic if
applied at a high frequency (5 to 50 Hz). Such high frequency low
magnitude strains comprise an important constituent of a bone's strain
history, suggesting that these mechanical events could represent a
significant determinant of bone morphology. We hypothesize that small
increases in high frequency loading, introduced non-invasively into the
skeleton via vibration, will stimulate an increase in bone mass without
sacrificing bone quality. Considering these strain levels are well below
(<1/100th) those which may cause damage to the tissue, we believe these
signals hold great potential as a mechanical prophylaxis for osteopenia.
Using skeletally mature sheep, a randomized, partial 5x4x3 factorial
experimental design, evaluating frequency (7.5, 15, 30, 60 or 120 Hz),
duration (5, 10, 20 or 40 min), and intensity (0.1, 0.2 or 0.4g) will be
used to determine the efficacy of a non-invasive mechanical device to
augment the trabeculae of the tibia and femur. A series of in vivo and
ex vivo protocols will be used to quantify the ability of this twelve
month mechanical intervention to affect both bone mass and morphology.
Dual energy x-ray absorptiometry will determine changes in density as a
function of time, dynamic and static histomorphometry will quantify the
site-specificity, quality, and extent of the response, and mechanical
testing will be used to determine if this treatment influences strength
and stiffness of the treated regions of the skeleton. Finally, the most
osteogenic mechanical signals will be used to determine if bone density,
strength, and stiffness can be recovered in the osteopenic skeleton.
These experiments may yield new insights into the mechanisms by which
mechanical factors control bone morphology, as well as lead to a novel
treatment for osteoporosis.
这个实验室的初步工作已经证明了这是极低的
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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CLINTON T RUBIN其他文献
CLINTON T RUBIN的其他文献
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{{ truncateString('CLINTON T RUBIN', 18)}}的其他基金
INTERDISCIPLINARY RESEARCH PROGRAM FOR UNDERGRADUATES
本科生跨学科研究计划
- 批准号:
6722812 - 财政年份:2001
- 资助金额:
$ 27.19万 - 项目类别:
INTERDISCIPLINARY RESEARCH PROGRAM FOR UNDERGRADUATES
本科生跨学科研究计划
- 批准号:
6636571 - 财政年份:2001
- 资助金额:
$ 27.19万 - 项目类别:
INTERDISCIPLINARY RESEARCH PROGRAM FOR UNDERGRADUATES
本科生跨学科研究计划
- 批准号:
6233054 - 财政年份:2001
- 资助金额:
$ 27.19万 - 项目类别:
INTERDISCIPLINARY RESEARCH PROGRAM FOR UNDERGRADUATES
本科生跨学科研究计划
- 批准号:
6520401 - 财政年份:2001
- 资助金额:
$ 27.19万 - 项目类别:
Augmentation of Trabecular Bone by Low Magnitude Strain
通过低强度应变增强骨小梁
- 批准号:
7582929 - 财政年份:1996
- 资助金额:
$ 27.19万 - 项目类别:
AUGMENTATION OF TRABECULAR BONE BY LOW MAGNITUDE STRAIN
通过低强度应变增强骨小梁
- 批准号:
2607929 - 财政年份:1996
- 资助金额:
$ 27.19万 - 项目类别:
AUGMENTATION OF TRABECULAR BONE BY LOW MAGNITUDE STRAIN
通过低强度应变增强骨小梁
- 批准号:
6950036 - 财政年份:1996
- 资助金额:
$ 27.19万 - 项目类别:
Augmentation of Trabecular Bone by Low Magnitude Strain
通过低强度应变增强骨小梁
- 批准号:
7688652 - 财政年份:1996
- 资助金额:
$ 27.19万 - 项目类别:
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