PRENATAL COCAINE EXPOSURE EFFECTS ON LEARNING IN RATS

产前接触可卡因对大鼠学习的影响

• 批准号: 2749050
• 负责人: DARLENE H BRUNZELL
• 金额: $ 1.6万
• 依托单位: UNIVERSITY OF MASSACHUSETTS AMHERST
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-07-10 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/2749050
• 关键词: animal developmental psychology; behavioral /social science research tag; cocaine; disease /disorder model; embryo /fetus toxicology; female; gender difference; laboratory rat; learning; neuroanatomy

Federal and state governments have a responsibility to provide education which is tailored to the ability of each individual child. With a prevalence of cocaine abuse among pregnant women, it is critical to determine if their exposed children exhibit learning and/or memory deficits that would require special educational attention. The validity of human studies is compromised by confounding variables which are difficult to control for. The main objective of this project is to generate an animal-learning preparation which institutes complicated learning tasks that could target the teratogenic effects of cocaine exposure and be adapted for human screening purposes. Gravid dams will be randomly assigned to either a low-dose cocaine treatment group, a high- dose cocaine treatment group, a vehicle and pair-fed control group, or an untreated control group to determine if adult offspring of the cocaine- treated dams show a learning deficit.

联邦和州政府有责任提供教育 根据每个孩子的能力量身定制。 与 鉴于孕妇滥用可卡因的普遍性，至关重要的是 确定他们接触过的孩子是否表现出学习和/或记忆 需要特别教育关注的缺陷。 有效性 人类研究的结果受到混杂变量的影响， 难以控制。 该项目的主要目标是 产生一种复杂的动物学习准备 针对可卡因致畸作用的学习任务 暴露并适于人类筛查目的。 妊娠母鼠将 随机分配到低剂量可卡因治疗组，高剂量可卡因治疗组， 剂量可卡因治疗组、媒介物和成对喂食对照组或 未处理的对照组，以确定是否成年后代的可卡因- 处理的母鼠表现出学习缺陷。