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MOLECULAR ASPECTS OF MRI CONTRAST AGENTS SELECTIVITY

MRI 造影剂选择性的分子方面

基本信息

批准号：
2895815
负责人：
TATYANA I SMIRNOVA
金额：
$ 3.67万
依托单位：
UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
依托单位国家：
美国
项目类别：
财政年份：
1999
资助国家：
美国
起止时间：
1999-06-01 至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/2895815
关键词：
bioimaging /biomedical imaging chemical binding chemical structure function contrast media magnetic resonance imaging

项目摘要

Contrast-enhanced magnetic resonance imaging (MRI) is a very effective clinical diagnostic technique. However, most paramagnetic contrast agents (PCA) enhance image contrast purely on the basis of nonspecific bio- distribution properties, which is sometimes enough to visualize some biochemical events. Currently, there are some gaps in understanding of the structure-function relationship of PCA, molecular mechanism of reversible binding of PCA to biological micromolecules, and the effect of biological environment on relaxivity of PCA. The broad objectives of the proposed project are to understand molecular aspects of binding and interactions of PCA molecules developed for clinical MRI applications with several key biomolecules, such as plasma proteins and phospholipids, and the relationship between binding and relaxation enhancement. The goal will be achieved by characterization of binding interaction and by investigating effects of these interactions on structure and electronic properties of PCA's through systematic study of several classes Gd3+ complexes by a variety of spectroscopic techniques, including fluorescence, nuclear magnetic resonance, and electron paramagnetic resonance at multiple and high frequencies. This key information is essential to guide development of new, more effective contrast agents with enhanced relaxivity and selectivity.

对比增强磁共振成像（MRI）是一种非常有效的检查方法。临床诊断技术。然而，大多数顺磁性造影剂（PCA）纯粹基于非特异性生物增强图像对比度分布属性，有时足以可视化一些生化事件。目前，人们对这一问题的认识还存在一些差距。 PCA结构-功能关系、可逆分子机制 PCA与生物小分子的结合，以及生物小分子的作用环境对 PCA 松弛度的影响。拟议的广泛目标项目的目的是了解结合和相互作用的分子方面 PCA 分子专为临床 MRI 应用而开发，具有几个关键特性生物分子，例如血浆蛋白和磷脂，以及结合与弛豫增强之间的关系。目标将是通过结合相互作用的表征和研究来实现这些相互作用对结构和电子性质的影响 PCA 通过对几类 Gd3+ 复合物的系统研究各种光谱技术，包括荧光、核磁共振和电子顺磁共振在多个和高频率。这些关键信息对于指导开发至关重要新型、更有效的造影剂，具有增强的弛豫度和选择性。