INTERACTION OF MRI GD CONTRAST AGENTS W/ MEMBRANES AS STUDIED BY HF EPR
INTERACTION OF MRI GD CONTRAST AGENTS W/ MEMBRANES AS STUDIED BY HF EPR
批准号:
6120619
负责人:
TATYANA I SMIRNOVA
金额:
$0.32万
依托单位国家:
美国
项目类别:
财政年份:
1998
资助国家:
美国
项目状态:
已结题
起止时间:
1998-04-15 至 1999-11-30
中文摘要
两种MRI钆造影剂的相互作用,钆
乙氧基苄基-二亚乙基三胺五乙酸酯(Gd-EOB-DTPA)和
钆2-戊基-(1,4,7,10-四氮杂环十二烷-N,N ',N ",
N ""-四乙酸)(Gd-DOTA-P),与多层磷脂
分散体,其制备自
1,2-二棕榈酰-sn-甘油-3-磷脂酰胆碱(DPPC)已被
在95 GHz的高分辨率EPR光谱研究。 在
3.3T EPR谱的共振场,
2,2,6,6-四甲基-1-哌啶基氧基(克里思),分配在
水相和膜相清晰地分离,
测头的动力学参数的准确性和明确性。 结果
显示尽管存在更亲脂的造影剂,
Gd-DOTA-P,可以在双层内检测到,
膜的组织即使在
生理高浓度(5mM)。 的温度
双层的主要相变也不受影响,
在0.4oC的测定精度范围内。
英文摘要
Interactions of two MRI gadolinium contrast agents, gadolinium
ethoxybenzyl-diethylenetriaminepentaacetate (Gd-EOB-DTPA) and
gadolinium 2-pentyl-(1,4,7,10-tetraazacyclododecane-N, N', N'',
N'''-tetraacetic acid) (Gd-DOTA-P), with multibilayer phospholipid
dispersions prepared from
1,2-dipalmitoyl-sn-glycero-3-phosphatidylcholine (DPPC) have been
investigated with high resolution EPR spectroscopy at 95 GHz. At a
resonance field of 3.3 T EPR spectra of a small nitroxide probe,
2,2,6,6-tetramethyl-1-piperidinyloxy (Tempo), partitioned between
aqueous and membrane phases are clearly resolved, making measurements
of dynamics parameters of the probe accurate and unambiguous. Results
show that although the presence of the more lipophilic contrast agent,
Gd-DOTA-P, can be detected within the bilayer, the structural
organization of the membrane remains unaffected even at
physiologically high (5mM) concentrations. The temperature of the
main phase transition of the bilayer was also unaffected to
within the 0.4oC accuracy of its determination.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
UNFOLDING OF CONCANAVALIN A BY HIGH FIELD EPR AND CD
-
批准号:6977637
-
项目类别:
-
资助金额:$0.25万
-
财政年份:2004
-
负责人:TATYANA I SMIRNOVA
-
依托单位:
MOLECULAR ASPECTS OF MRI CONTRAST AGENTS SELECTIVITY
-
批准号:2895815
-
项目类别:
-
资助金额:$3.67万
-
财政年份:1999
-
负责人:TATYANA I SMIRNOVA
-
依托单位:
HIGH FREQUENCY (95 GHZ) EPR SPECTROSCOPY TO CHARACTERIZE SPIN ADDUCTS
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批准号:6120683
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项目类别:
-
资助金额:$0.27万
-
财政年份:1998
-
负责人:TATYANA I SMIRNOVA
-
依托单位:
MOLECULAR ASPECTS OF MRI CONTRAST AGENTS SELECTIVITY
-
批准号:2712839
-
项目类别:
-
资助金额:$2.62万
-
财政年份:1998
-
负责人:TATYANA I SMIRNOVA
-
依托单位:
HIGH FREQUENCY (95 GHZ) EPR SPECTROSCOPY TO CHARACTERIZE SPIN ADDUCTS
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批准号:6251812
-
项目类别:
-
资助金额:$0.42万
-
财政年份:1997
-
负责人:TATYANA I SMIRNOVA
-
依托单位:
MOLECULAR ASPECTS OF MRI CONTRAST AGENTS SELECTIVITY
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批准号:2011188
-
项目类别:
-
资助金额:$2.43万
-
财政年份:1997
-
负责人:TATYANA I SMIRNOVA
-
依托单位:
W BAND EPR OF NITROXIDES W/ COMPLEX SUPERHYPERFINE STRUCTURE: FAST MOTION
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批准号:6251772
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项目类别:
-
资助金额:$0.42万
-
财政年份:1997
-
负责人:TATYANA I SMIRNOVA
-
依托单位:
INTERACTION OF MRI GD CONTRAST AGENTS W/ MEMBRANES AS STUDIED BY HF EPR
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批准号:6251818
-
项目类别:
-
资助金额:$0.42万
-
财政年份:1997
-
负责人:TATYANA I SMIRNOVA
-
依托单位:
W BAND EPR OF NITROXIDE W/ COMPLEX SUPER HYPERFINE STRUCTURE: FAST MOTION
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批准号:5223639
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项目类别:
-
资助金额:$0.0万
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财政年份:--
-
负责人:TATYANA I SMIRNOVA
-
依托单位:--
HALF FIELD EPR TRANSITIONS IN SYNTHETIC CARBOHYDRATE CHARS
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批准号:5223638
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项目类别:
-
资助金额:$0.0万
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财政年份:--
-
负责人:TATYANA I SMIRNOVA
-
依托单位:--
ACCURACY OF OXYGEN MEASUREMENTS IN T2 (LINEWIDTH) EPR OXIMETRY
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批准号:5223640
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项目类别:
-
资助金额:$0.0万
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财政年份:--
-
负责人:TATYANA I SMIRNOVA
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依托单位:--
MAGNETIC PROPERTIES OF COAL & CHAR MATERIALS MEASURED BY EPR & SQUID
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批准号:5223616
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:TATYANA I SMIRNOVA
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依托单位:--
FUSINITE AS POSSIBLE EPR STANDARD
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批准号:5223618
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:TATYANA I SMIRNOVA
-
依托单位:--
海外基金