BASAL GANGLIA FUNCTION IN OBSESSIVE COMPULSIVE DISORDER

强迫症中的基底神经节功能

• 批准号: 2884959
• 负责人: SCOTT L RAUCH
• 金额: $ 28.87万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-08-01 至 2004-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2884959
• 关键词: basal ganglia; behavior test; behavioral /social science research tag; bioimaging /biomedical imaging; cerebral dominance; clinical research; cognition; corpus striatum; disease /disorder classification; functional magnetic resonance imaging; human middle age (35-64); human subject; learning; memory; mental disorder diagnosis; neural information processing; neuropathology; neuropsychology; obsessive compulsive disorder; psychomotor function; remission /regression; thalamus; visual stimulus; young adult human (21-34)

The goals of this project are to test specific hypotheses about the pathophysiology of obsessive compulsive disorder (OCD) using functional MRI (fMRI) and cognitive neuroscience methods. The basal ganglia have been implicated in the pathophysiology of OCD and also in the normal mediating anatomy of implicit (i.e., nonconscious) learning. We have developed an fMRI paradigm to measure activity within components of the basal ganglia during the performance of an implicit learning task. In preliminary functional imaging studies, we have observed an abnormal activation profile in medication-free subjects with current OCD. Specifically, in comparison to normal control subjects, patients with OCD exhibit a failure to activate right striatum, and an absence of thalamic deactivation, as well as aberrent medial temporal activation (i.e., not found in normal subjects). These results are consistent with evolving neurobiological models of OCD and basal ganglia function. The current proposal aims to: 1) use this fMRI paradigm to replicate and elaborate upon the above findings in a larger cohort of medication-free patients with active OCD and matched normal comparison subjects; 2) determine the specificity of the findings in OCD by studying psychiatric comparison subjects; and 3) further investigate the neuropsychological consequences of the abnormal activation profile observed in OCD. It is anticipated that this approach will yield new information regarding the pathophysiology of OCD and related disorders, while providing new insights about the normal function of the basal ganglia and the mediating anatomy of normal learning.

本项目的目的是使用功能性磁共振成像（fMRI）和认知神经科学的方法来测试有关强迫症（OCD）的病理生理学的特定假设。 基底神经节与强迫症的病理生理学有关，也与内隐（即，无意识的学习。 我们已经开发了一个功能磁共振成像范式来测量内隐学习任务的执行过程中的基底神经节的组成部分的活动。 在初步的功能成像研究中，我们已经观察到一个异常的激活配置文件在当前的强迫症患者的药物自由。具体地，与正常对照受试者相比，患有OCD的患者表现出激活右纹状体的失败，以及丘脑失活的缺乏，以及异常的内侧颞叶激活（即，在正常受试者中未发现）。 这些结果与不断发展的强迫症和基底神经节功能的神经生物学模型是一致的。 本提案旨在：1）使用这种功能性磁共振成像范例在更大的无药物治疗的活动性强迫症患者和匹配的正常对照受试者队列中复制和阐述上述发现; 2）通过研究精神病学对照受试者来确定强迫症中发现的特异性; 3）进一步研究在强迫症中观察到的异常激活特征的神经心理学后果。 预计这种方法将产生有关强迫症和相关疾病的病理生理学的新信息，同时提供有关基底神经节的正常功能和正常学习的介导解剖学的新见解。