Super-resolution, low cost optical bio-nanoscope for direct virus imaging

用于直接病毒成像的超分辨率、低成本光学生物纳米镜

• 批准号: 99090
• 金额: $ 44.52万
• 依托单位: LIG NANOWISE LIMITED
• 依托单位国家: 英国
• 项目类别: Collaborative R&D
• 财政年份: 2021
• 资助国家: 英国
• 起止时间: 2021 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=99090
• 关键词: Super; resolution; low; cost; optical

Coronaviruses are threatening the lives of human being worldwide. Understanding of coronaviruse interactions with cells and drugs is essential for the development of treatments and prevention of future pandemics. LIG Nanowise Ltd will develop a new super-resolution, low cost optical microscope at 50 nm direct optical resolution that can see live viruses including coronavirus (60-140 nm in size) and their interactions with cells and drugs to accelerate drug discovery and diagnosis of diseases. Current electron microscopes and other optical microscopes cannot visualise live viruses due to the requirement for vacuum operation or the injection of fluorescent materials into the viruses or low optical resolution (a theoretical resolution limit of 200 nm for standard optical microscopes).

冠状病毒正威胁着全世界人类的生命。了解冠状病毒与细胞和药物的相互作用对于开发治疗方法和预防未来的流行病至关重要。LIG Nanowise公司将开发一种新的超分辨率，低成本的光学显微镜，直接光学分辨率为50 nm，可以看到活病毒，包括冠状病毒（大小为60-140 nm）及其与细胞和药物的相互作用，以加速药物发现和疾病诊断。目前的电子显微镜和其他光学显微镜无法可视化活病毒，因为需要真空操作或将荧光材料注入病毒或低光学分辨率（标准光学显微镜的理论分辨率限制为200 nm）。