具有多效性基因的贝叶斯分析-猫眼课题宝

具有多效性基因的贝叶斯分析

批准号：

2822832

负责人：

STEVEN MATTHYSSE

金额：

$7.25万

依托单位：

MCLEAN HOSPITAL

依托单位国家：

美国

项目类别：

财政年份：

1998

资助国家：

美国

项目状态：

已结题

起止时间：

1998-12-01 至 2001-11-30

来源：

https://reporter.nih.gov/project-details/2822832

关键词：

computer data analysis computer program /software computer simulation diagnosis quality /standard family genetics gene expression gene frequency genetic disorder genetic markers genetic models human data linkage mapping mathematical model pleiotropism

中文摘要

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英文摘要

The need for linkage and segregation analysis programs for general pedigrees that can handle epistatic effects of several genes, and multiple marker loci, is generally recognized. The approach to this goal taken in this project has three distinctive aspects: 1) Inclusion of pleiotropic effects on several qualitative or quantitative traits. 2) A Bayesian perspective on linkage and segregation analysis that is, so to speak, half-way between model-dependent and non-parametric methods. 3) A conservative approach to Markov chain Monte Carlo, using it primarily in contexts where it is possible to find lower bounds on its rate of convergence.

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