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CONVERGENCE RATES OF MARKOV CHAINS IN GENETIC ANALYSIS

遗传分析中马尔可夫链的收敛率

基本信息

批准号：
6386875
负责人：
STEVEN MATTHYSSE
金额：
$ 16.6万
依托单位：
MCLEAN HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
1999
资助国家：
美国
起止时间：
1999-08-01 至 2004-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6386875
关键词：
computer simulation gene frequency genetic techniques homozygote linkage mapping method development

项目摘要

DESCRIPTION (Adapted from applicant abstract): The objective of this project is to construct rigorous lower bounds on the convergence rates of Markov chains used in genetic analysis, in order that the Markov chain Monte Carlo (MCMC) technique can be used with greater confidence. This technique, since its introduction into segregation and linkage analysis in 1989, has had an ever increasing number of applications, and it is widely believed to be the ideal method for linkage analyses that take into account sources of uncertainty (such as allele frequencies, diagnostic misclassification, typing errors, map location uncertainities, epistasis, partial penetrance and sex effects), and also for segretation analyses that include multiple genes and multiple traits, interacting according to the complex patterns expected in neuropsychiatric disorders. It is also widely recognized that the major weakness of MCMC is the absence of any way to be certain that the Markov chain has adequately converged. While there are many "convergence diagnostics" in the literature, they can provide only necessary, not sufficient, conditions. This problem becomes 3specially worrisome when MCMC techniques are applied by general users for complex models with many parameters. Finding rigorous lower bounds on MCMC convergence rates will make possible secure guidelines for using the method, and lay the groundwork for more ambitious applications of MCMC in genetics in the future.

描述（改编自申请人摘要）：本项目的目标是构造马尔可夫链收敛速度的严格下界用于遗传分析，以便马尔可夫链蒙特卡罗（MCMC）技术可以更有信心地使用。这项技术，因为它 1989年引入分离和连锁分析，越来越多的应用程序，它被广泛认为是理想的考虑到不确定性来源（如如等位基因频率，诊断错误分类，分型错误，地图位置不确定性、上位性、部分易位和性别效应），以及同样对于包括多个基因和多个性状的分离分析，根据神经精神病学中预期的复杂模式相互作用紊乱人们还普遍认识到，MCMC的主要弱点是没有任何方法可以确定马尔可夫链充分融合虽然文献中有许多“收敛诊断”，它们只能提供必要的而不是充分的条件。这个问题当一般用户应用MCMC技术时，具有许多参数的复杂模型。求MCMC的严格下界收敛速率将使得使用该方法的安全准则成为可能，并为MCMC在遗传学中更雄心勃勃的应用奠定基础，未来