MAIESE SCIENTIFIC PROGRAM

麦斯科学计划

• 批准号: 6203319
• 负责人: WILLIAM M MAIESE
• 金额: $ 9.68万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-15 至 2000-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6203319
• 关键词: Actinomycetales; antineoplastics; aquatic organism; biological products; chemical structure function; drug discovery /isolation; drug screening /evaluation; fermentation; marine biology; microorganism classification; microorganism metabolism; neoplasm /cancer pharmacology; water microbiology

The goal of this proposed research is to isolate novel anticancer agents produced by microorganisms (actinomycEtales, eubacteria and fungi) from the marine environment. This endeavor includes: l) Isolation of microorganisms from diverse marine environments, including those living in close association with marine animals and plants 2) Taxonomic identification of these microorganisms and cataloging by type and substrate specificity 3) Fermentation for production of bioactive compounds and to provide extracts for testing in CODS 4) Isolation and characterization of these active compounds

这项拟议的研究的目的是隔离新型抗癌剂 微生物产生的药物（放线菌，Eubacteria和 真菌）来自海洋环境。这项工作包括： l）从各种海洋环境中隔离微生物， 包括与海洋动物密切关联的人以及 植物 2）分类学鉴定这些微生物和通过 类型和底物特异性 3）生产生物活性化合物的发酵并提供 用于测试的摘录 4）这些活性化合物的隔离和表征