IMMUNOLOGIC FACTORS IN SALIVA & BLOOD

唾液中的免疫因素

• 批准号: 2823577
• 负责人: Neal T Wetherall
• 金额: $ 17.68万
• 依托单位: VIROMED LABORATORIES, INC.
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-06-03 至 2000-11-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2823577
• 关键词: HIV infections; antiviral antibody; elastases; enzyme linked immunosorbent assay; human immunodeficiency virus; human tissue; immunoglobulins; in situ hybridization; lactoferrin; lactoperoxidase; lysozyme; method development; mucins; neoplasm /cancer immunology; neutralizing antibody; oral health; phenotype; provirus; saliva; serum; thrombospondins; tissue /cell culture; virus DNA; virus infection mechanism

This acquisition is for laboratory support for an NIDR study which is analyzing the clinical and medical conditions and selected immunological, behavioral, and other potential determinants of oral and systemic disease collected from a cohort of HIV-positive military personnel from 1987 to 1994 by the Walter Reed Army Institute of Research. The NIDR participated in this protocol to study the natural history of oral consequences of HIV infection. More than 800 subjects were enrolled in the oral health component from 1989 to 1994 and returned every six months for re-evaluation of their oral health status and for other tests and procedures. The purpose of the project is to assess the salivary HIV and salivary antiviral defense mechanisms in the saliva and serum of the study participants and relate these factors to the occurrence and progression of oral and systemic manifestations of HIV. The contract will support the NIDR study by undertaking the required laboratory assessments and the development of laboratory assay procedures to handle some special features of this particular research study, such as the large volume of samples and the need for procedures to conserve volume of specimen as much as possible.

此次收购是为NIDR研究提供实验室支持， 分析临床和医疗条件， 免疫学、行为学和其他可能的口腔疾病决定因素， 从HIV阳性军人队列中收集的全身性疾病 1987年至1994年，沃尔特里德陆军研究所 Research. NIDR参与了这项协议，以研究自然 艾滋病毒感染的口腔后果史。 800多个科目 在1989年至1994年期间参加了口腔健康部分， 每六个月返回一次，重新评估他们的口腔健康状况 以及其他测试和程序。 该项目的目的是 评估唾液HIV和唾液抗病毒防御机制， 研究参与者的唾液和血清，并将这些因素与 口腔和全身表现的发生和进展 艾滋病。 该合同将支持NIDR的研究， 所需的实验室评估和实验室检测的开发 处理这项研究的一些特殊特征的程序 研究，如大量的样品和程序的需要 尽可能保存标本体积。