PROVIDE BIOANALYTICAL CHEMISTRY SUPPORT

提供生物分析化学支持

• 批准号: 2711942
• 负责人: DAVID B GARCIA
• 金额: $ 3.47万
• 依托单位: SEA PHARMACEUTICAL SCIENCES, INC.
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-05-15 至 1997-08-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2711942
• 关键词: analytical method; carcinogen testing; chemical carcinogen; chemical carcinogenesis; toxicant screening; toxin metabolism

The purpose of this project, entitled "Bioanalytical Chemistry Support", is to provide bioanalytical chemistry support services to support the long term toxicity and carcinogenesis studies as well as in house research efforts for the National Toxicology Program (NTP). The project will be divided into three tasks: In Task 1, the contractor shall validate analytical methods to quantitate test chemicals, biotransformation products or other specified substances in biological materials. These validations shall be for methods that are available and when the anticipated concentrations in the biological samples are known. In Task 2 the contractor shall develop analytical methods to quantitate test chemicals, biotransformation products or other specified substances in biological materials. This developmental work shall include the analysis of a limited number of samples from dosed animals to determine the appropriate concentration range over which to develop the method. Validation of the method shall then be conducted over the determined range. In Task 3 the contractor shall determine the concentration of test chemical biotransformation products or other specified substances in biological materials, using previously developed and validated methods. The contractor shall be responsible for disposing toxic wastes, such as excess test chemicals, biological fluids, and tissues in accordance with all applicable federal, state and local laws and regulations.

该项目名为“生物分析化学支持”，其目的是 提供生物分析化学支持服务， 长期毒性和致癌性研究以及内部研究 国家毒理学计划（NTP）。 该项目将 分为三项任务：在任务1中，承包商应确认 定量测试化学品、生物转化产物的分析方法 或生物材料中的其他特定物质。 这些验证 应适用于可用的方法，并且当预期 已知生物样品中的浓度。 在任务2中， 承包商应制定分析方法，以定量测试化学品， 生物转化产品或生物制品中的其他特定物质 材料. 这项开发工作应包括分析有限的 给药动物的样品数量，以确定适当的 浓度范围，以开发该方法。 验证 然后在确定的范围内进行方法。 在任务3中， 承包商应确定试验化学品的浓度 生物转化产品或生物制品中的其他特定物质 材料，使用以前开发和验证的方法。 的 承包商应负责处理有毒废物，如过量的 测试化学品，生物液体和组织，按照所有 适用的联邦、州和地方法律法规。