CLIN CTR CLIN TRIAL/OBSERVATIONAL STUDY OF WHI

CLIN CTR WHI 临床试验/观察研究

• 批准号: 2873989
• 负责人: HOWARD L JUDD
• 金额: $ 80.31万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-09-30 至 2005-09-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2873989
• 关键词: breast neoplasms; calcium; clinical research; clinical trials; colorectal neoplasms; coronary disorder; diet; disease /disorder prevention /control; disease /disorder proneness /risk; estrogens; female; hip fractures; hormone therapy; human middle age (35-64); human old age (65+); human subject; human therapy evaluation; longitudinal human study; nutrition related tag; osteoporosis; postmenopause; quality of life; questionnaires; stroke; therapy compliance; vitamin D; women's health

The Women's Health Initiative is a randomized controlled clinical trial conducted in 40 clinical centers across the United States addressing some of the most common causes of death, disability, and impaired quality of life in postmenopausal women ages 50-79: cardiovascular disease; breast and colon cancer; and osteoporosis. The three components of this disease prevention trial are: (1) hormone replacement therapy with a primary outcomes of coronary heart disease and stroke and secondary outcomes of hip and other fractures; (2) low fat dietary intervention with primary outcomes of breast cancer and colorectal cancer and a secondary outcome of coronary heart disease; and (3) calcium and vitamin D supplementation with a primary outcome of hip fractures and secondary outcomes of colorectal cancer and combined fractures. A concurrent observational study will provide estimates of health effects of known risk factors and new predictors for disease. Each clinical center will collect data through questionnaires and biological specimens over 8-12 years.

妇女健康倡议是一项随机对照临床研究， 在美国40个临床中心进行的试验 解决一些最常见的死亡、残疾和 50-79岁绝经后妇女的生活质量受损： 心血管疾病;乳腺癌和结肠癌;以及骨质疏松症。 这项疾病预防试验的三个组成部分是：（1） 激素替代治疗与冠状动脉病变主要结局 心脏病和中风以及髋关节和其他 骨折;（2）低脂饮食干预与主要结局 乳腺癌和结直肠癌的次要结局是 冠心病;（3）钙和维生素D 补充主要结局为髋部骨折， 结直肠癌和合并骨折的次要结局。一 同时进行的观察性研究将提供健康评估 已知的危险因素和疾病的新预测因素的影响。每个 临床中心将通过问卷调查收集数据， 8-12年的生物标本。