VANGUARD CENTER FOR WOMEN'S HEALTH INITIATIVE

妇女健康倡议是一项随机对照临床试验 在全美40个临床中心进行的试验 解决一些最常见的死亡、残疾和 50-79岁绝经后妇女生活质量受损： 心血管疾病；乳腺癌和结肠癌；以及骨质疏松症。 这项疾病预防试验的三个组成部分是：(1) 以冠状动脉病变为主要结局的激素替代疗法 心脏病和中风以及髋关节和其他疾病的继发性结局 骨折；(2)低脂饮食干预与主要结果 乳腺癌和结直肠癌的风险，以及 冠心病；以及(3)钙和维生素D 补充髋部骨折的主要结果和 结直肠癌和合并骨折的二次转归。一个 同时进行的观察性研究将提供健康状况的估计 已知的危险因素和新的疾病预测因子的影响。每个人 临床中心将通过问卷调查和 8-12年的生物标本。

The Women's Health Initiative is a randomized controlled clinical trial conducted in 40 clinical centers across the United States addressing some of the most common causes of death, disability, and impaired quality of life in postmenopausal women ages 50-79: cardiovascular disease; breast and colon cancer; and osteoporosis. The three components of this disease prevention trial are: (1) hormone replacement therapy with a primary outcomes of coronary heart disease and stroke and secondary outcomes of hip and other fractures; (2) low fat dietary intervention with primary outcomes of breast cancer and colorectal cancer and a secondary outcome of coronary heart disease; and (3) calcium and vitamin D supplementation with a primary outcome of hip fractures and secondary outcomes of colorectal cancer and combined fractures. A concurrent observational study will provide estimates of health effects of known risk factors and new predictors for disease. Each clinical center will collect data through questionnaires and biological specimens over 8-12 years.