CANCER EPIDEMIOLOGY IN A LARGE HEALTH CARE PLAN

我建议继续我们在癌症流行病学方面的工作， 在过去的15年里， 并已支持了4年的杰出研究人员赠款， 具体如下： 1. 继续监测药物的可能致癌作用 143，574名凯撒基金会健康计划成员的队列中使用药物， 程序的额外数据资源来测试假设。 研究更新 酌情使用新的全区域药房数据系统 目前正在实施。 2. 继续对100 000多人的队列进行跟踪， 多阶段健康检查加上关于吸烟和 酒精的使用，研究各种烟草的致癌作用 产品，酒精饮料，大麻和其他因素。 3. 继续进行可能的巢式病例对照研究 在上述多阶段队列中，使用大的 收集冷冻血清标本。 4. 继续研究筛查试验在 预防癌症死亡。 5. 利用杰出研究者补助金提供的灵活性 研究有关癌症病因学和控制的有前途的新线索， 凯撒医疗机构的丰富数据资源。

I propose to continue our work in cancer epidemiology that has developed at the Kaiser Permanente Medical Care Program in the past 1 1/2 decades and has been supported for 4 years by an Outstanding Investigators Grant, as follows: 1. Continue surveillance for possible carcinogenic effects of medicinal drugs in a cohort of 143,574 Kaiser Foundation Health Plan members using additional data resources of the program to test hypotheses. Study newer drugs, as appropriate, using the new region-wide pharmacy data system that is currently being implemented. 2. Continue follow-up of a cohort of over 100,000 persons who received multiphasic health checkups plus research questionnaires on smoking and alcohol use, to study cancer-producing effects of various tobacco products, alcoholic beverages, marijuana and other factors. 3. Continue to conduct nested case-control studies of possible chemopreventive factors in the above multiphasic cohort using a large collection of frozen serum specimens. 4. Continue to conduct studies of the efficacy of screening tests in preventing mortality from cancer. 5. Employ the flexibility afforded by the Outstanding Investigator Grant to study promising new leads concerning cancer etiology and control in the extensive data resources of Kaiser Permanente.