CANCER EPIDEMIOLOGY IN A LARGE HEALTH CARE PLAN

大型医疗保健计划中的癌症流行病学

• 批准号: 6076563
• 负责人: GARY D FRIEDMAN
• 金额: $ 56.45万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-06-01 至 2001-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6076563
• 关键词: alcoholic beverage consumption; automated medical record system; biomarker; cancer prevention; cancer registry /resource; chemoprevention; drug carcinogenesis; human population study; human subject; mammography; managed care; mass screening; neoplasm /cancer epidemiology; questionnaires; smoking; tumor antigens; urinalysis

I propose to continue our work in cancer epidemiology that has developed at the Kaiser Permanente Medical Care Program in the past 1 1/2 decades and has been supported for 4 years by an Outstanding Investigators Grant, as follows: 1. Continue surveillance for possible carcinogenic effects of medicinal drugs in a cohort of 143,574 Kaiser Foundation Health Plan members using additional data resources of the program to test hypotheses. Study newer drugs, as appropriate, using the new region-wide pharmacy data system that is currently being implemented. 2. Continue follow-up of a cohort of over 100,000 persons who received multiphasic health checkups plus research questionnaires on smoking and alcohol use, to study cancer-producing effects of various tobacco products, alcoholic beverages, marijuana and other factors. 3. Continue to conduct nested case-control studies of possible chemopreventive factors in the above multiphasic cohort using a large collection of frozen serum specimens. 4. Continue to conduct studies of the efficacy of screening tests in preventing mortality from cancer. 5. Employ the flexibility afforded by the Outstanding Investigator Grant to study promising new leads concerning cancer etiology and control in the extensive data resources of Kaiser Permanente.

我建议继续我们在癌症流行病学方面的工作 过去 1.5 年来在 Kaiser Permanente 医疗护理计划中的经历 并已获得杰出研究者补助金长达 4 年的支持， 如下： 1. 继续监测药物可能的致癌作用 143,574 名 Kaiser 基金会健康计划成员使用的药物 程序的额外数据资源用于检验假设。 学习更新 酌情使用新的区域药房数据系统 目前正在实施。 2. 继续对超过 100,000 名接受过治疗的人进行随访 多阶段健康检查以及有关吸烟和吸烟的研究问卷 饮酒，研究各种烟草的致癌作用 产品、酒精饮料、大麻和其他因素。 3. 继续开展可能的巢式病例对照研究 上述多相队列中的化学预防因素使用大量 收集冷冻血清标本。 4. 继续开展筛查试验的有效性研究 预防癌症死亡。 5. 利用杰出研究者补助金提供的灵活性 研究有关癌症病因学和控制的有希望的新线索 Kaiser Permanente 的广泛数据资源。