CANCER EPIDEMIOLOGY IN A LARGE HEALTH CARE PLAN

大型医疗保健计划中的癌症流行病学

• 批准号: 6172220
• 负责人: GARY D FRIEDMAN
• 金额: $ 70.34万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-06-01 至 2003-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6172220
• 关键词: alcoholic beverage consumption; automated medical record system; biomarker; cancer prevention; cancer registry /resource; chemoprevention; drug carcinogenesis; human population study; human subject; mammography; managed care; mass screening; neoplasm /cancer epidemiology; questionnaires; smoking; tumor antigens; urinalysis

I propose to continue our work in cancer epidemiology that has developed at the Kaiser Permanente Medical Care Program in the past 1 1/2 decades and has been supported for 4 years by an Outstanding Investigators Grant, as follows: 1. Continue surveillance for possible carcinogenic effects of medicinal drugs in a cohort of 143,574 Kaiser Foundation Health Plan members using additional data resources of the program to test hypotheses. Study newer drugs, as appropriate, using the new region-wide pharmacy data system that is currently being implemented. 2. Continue follow-up of a cohort of over 100,000 persons who received multiphasic health checkups plus research questionnaires on smoking and alcohol use, to study cancer-producing effects of various tobacco products, alcoholic beverages, marijuana and other factors. 3. Continue to conduct nested case-control studies of possible chemopreventive factors in the above multiphasic cohort using a large collection of frozen serum specimens. 4. Continue to conduct studies of the efficacy of screening tests in preventing mortality from cancer. 5. Employ the flexibility afforded by the Outstanding Investigator Grant to study promising new leads concerning cancer etiology and control in the extensive data resources of Kaiser Permanente.

我建议继续我们在癌症流行病学方面的工作 在过去的15年里，在凯撒永久医疗保健计划中 四年来一直由杰出调查员补助金资助， 详情如下： 1.继续监测药物可能的致癌作用 凯撒基金会健康计划成员143,574人中的药物使用 程序的附加数据资源，用于检验假设。更新的研究 酌情使用新的全区域药房数据系统 目前正在实施这一点。 2.继续对收到 多阶段健康检查外加关于吸烟和 酒精使用，以研究不同烟草的致癌作用 产品、酒精饮料、大麻等因素。 3.继续开展可能的嵌套病例对照研究 以上多期队列中的化学预防因素 收集冰冻血清标本。 4.继续就筛查测试的成效进行研究 预防癌症死亡。 5.利用杰出调查员补助金所提供的灵活性 研究关于癌症病因和控制的有希望的新线索 Kaiser Permanente丰富的数据资源。

项目成果

Barbiturates and lung cancer: a re-evaluation.

巴比妥类药物和肺癌：重新评估。

• DOI: 10.1093/ije/28.3.375
• 发表时间: 1999
• 期刊: International journal of epidemiology
• 影响因子: 7.7
• 作者: Friedman,GD;Habel,LA
• 通讯作者: Habel,LA

Exposure to engine exhaust and risk of subsequent cancer.

暴露于发动机废气和随后患癌症的风险。

• 发表时间: 1993
• 期刊: Journal of occupational medicine. : official publication of the Industrial Medical Association
• 作者: VanDenEeden,SK;Friedman,GD
• 通讯作者: Friedman,GD

Risk for gastric lymphoma in persons with CagA+ and CagA- Helicobacter pylori infection.

CagA 和 CagA- 幽门螺杆菌感染者患胃淋巴瘤的风险。

• DOI: 10.1086/517346
• 发表时间: 1997
• 期刊: The Journal of infectious diseases
• 作者: Witherell,HL;Hansen,S;Jellum,E;Orentreich,N;Vogelman,JH;Parsonnet,J
• 通讯作者: Parsonnet,J

Psychiatrically-diagnosed depression and subsequent cancer.

• 发表时间: 1994
• 期刊: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
• 作者: G. Friedman

Vitamin D and prostate cancer: a prediagnostic study with stored sera.

• 发表时间: 1993-09
• 期刊: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
• 作者: Elizabeth H. Corder;Harry A. Guess;Barbara S. Hulka;Gary D. Friedman;Marianne Sadler;Robin T. Vollmer;Bruce Lobaugh;Marc K. Drezner;J. Vogelman;Norman Orentreich