SYNTHESIS OF BIOLOGICALLY ACTIVE MACROCYCLIC MOLECULES
生物活性大环分子的合成
基本信息
- 批准号:2857929
- 负责人:
- 金额:$ 10.83万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1998
- 资助国家:美国
- 起止时间:1998-01-15 至 2001-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
DESCRIPTION: (Principal Investigator's) The purpose of this research
program is to invent, develop, and apply synthetic methods to the synthesis
and study of architecturally complex bioactive natural products. The
synthetic strategies to be studied should allow for the rapid and efficient
preparation of targeted and allied molecules allowing for the evaluation and
study of their biological properties. The program will concentrate in three
areas: (a) The synthesis of a structurally unique class of macrocyclic
compounds, known as the phomactins. Recently isolated from a marine fungus,
these molecules have demonstrated marked biological properties.
Specifically, the phomactins can effect the function of platelet-activating
factor (PAF). PAF is a compound ubiquitous to the human body and implicated
in respiratory, inflammatory, and cardiovascular diseases. While PAF has
been the subject of an intense research effort, numerous questions
concerning its role in these diseases remain unanswered. Interestingly,
while the phomactins inhibit PAF-induced platelet aggregation, no effect on
adenosine diphosphate, arachidonic acid, and collagen-induced platelet
aggregation has been observed. Thus the phomactins represent a new type of
PAF antagonist. (b) The synthesis of a series of novel macrolactones known
as the amphidinolides. These compounds have attractive biological features,
especially antileukemic properties as well as activity towards rabbit
skeletal muscle actomysion ATPase. In addition to their impressive
antileukemic activity, these molecules have several striking structural
features, including the contrast of lipophilic and hydrophilic moieties as
well as the presence of both conjugated and non-conjugated dienes. (c) In
conjunction with these synthetic ventures it is planned that new
organometallic and free radical reactions be designed and investigated.
Particular interests include the development of catalytic methods involving
palladium, indium, tin, and silicon as well as a study of the 1,2-Wittig
rearrangement in complex molecule synthesis.
描述:(主要调查者)本研究的目的
计划是发明、开发并将合成方法应用于合成
以及研究具有复杂建筑结构的生物活性天然产物。这个
需要研究的综合策略应该考虑到快速和有效的
靶向和缔合分子的制备,允许评价和
研究它们的生物学特性。该计划将集中在三个方面
领域:(A)一类结构独特的大环化合物的合成
化合物,也就是所谓的褐马菌素。最近从一种海洋真菌中分离出来,
这些分子已显示出显著的生物学特性。
具体地说,Pomactins可以影响血小板激活功能。
系数(PAF)。PAF是一种对人体普遍存在的化合物,与
在呼吸系统、炎症和心血管疾病中。而PAF则拥有
一直是紧张研究的主题,无数的问题
关于它在这些疾病中的作用的问题仍未得到答复。有趣的是,
虽然假单胞菌素抑制PAF诱导的血小板聚集,但对
二磷酸腺苷、花生四烯酸和胶原诱导的血小板
观察到了聚集现象。因此,Pomactins代表了一种新型的
PAF拮抗剂。(B)一系列已知的新型大内酯的合成
就像双宾内酯一样。这些化合物具有诱人的生物学特性,
尤其是抗白血病特性以及对兔的活性
骨骼肌肌动肌动蛋白ATPase。除了令人印象深刻的
抗白血病活性,这些分子有几个惊人的结构
特征,包括亲油性和亲水性部分的对比
以及共轭和非共轭双烯的存在。(C)在
与这些合成企业相结合,计划推出新的
有机金属和自由基反应的设计和研究。
特别感兴趣的是开发催化方法,包括
钯、铟、锡和硅以及1,2-Wittig的研究
复杂分子合成中的重排。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
ROBERT E MALECZKA其他文献
ROBERT E MALECZKA的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('ROBERT E MALECZKA', 18)}}的其他基金
SYNTHESIS OF BIOLOGICALLY ACTIVE MACROCYCLIC MOLECULES
生物活性大环分子的合成
- 批准号:
6343586 - 财政年份:1998
- 资助金额:
$ 10.83万 - 项目类别:
SYNTHESIS OF BIOLOGICALLY ACTIVE MACROCYCLIC MOLECULES
生物活性大环分子的合成
- 批准号:
2463158 - 财政年份:1998
- 资助金额:
$ 10.83万 - 项目类别:
SYNTHESIS OF BIOLOGICALLY ACTIVE MACROCYCLIC MOLECULES
生物活性大环分子的合成
- 批准号:
2772151 - 财政年份:1998
- 资助金额:
$ 10.83万 - 项目类别:
SYNTHESIS OF BIOLOGICALLY ACTIVE MACROCYCLIC MOLECULES
生物活性大环分子的合成
- 批准号:
6076901 - 财政年份:1998
- 资助金额:
$ 10.83万 - 项目类别:
Synthesis of Biologically Active Macrocycle Molecules
生物活性大环分子的合成
- 批准号:
6573242 - 财政年份:1998
- 资助金额:
$ 10.83万 - 项目类别:
Synthesis of Biologically Active Macrocycle Molecules
生物活性大环分子的合成
- 批准号:
6892377 - 财政年份:1998
- 资助金额:
$ 10.83万 - 项目类别:
SYNTHESIS OF BIOLOGICALLY ACTIVE MACROCYCLIC MOLECULES
生物活性大环分子的合成
- 批准号:
2772152 - 财政年份:1998
- 资助金额:
$ 10.83万 - 项目类别:
Synthesis of Biologically Active Macrocycle Molecules
生物活性大环分子的合成
- 批准号:
6769341 - 财政年份:1998
- 资助金额:
$ 10.83万 - 项目类别:
Synthesis of Biologically Active Macrocycle Molecules
生物活性大环分子的合成
- 批准号:
7065264 - 财政年份:1998
- 资助金额:
$ 10.83万 - 项目类别:
SYNTHESIS OF BIOLOGICALLY ACTIVE MACROCYCLIC MOLECULES
生物活性大环分子的合成
- 批准号:
6139246 - 财政年份:1998
- 资助金额:
$ 10.83万 - 项目类别:
相似海外基金
Collaboration in Regulatory Systems Strengthening and Standardization Activities to Increase Global Access to Safe and Effective Biological Products.
加强监管系统和标准化活动方面的合作,以增加全球获得安全有效的生物产品的机会。
- 批准号:
10448926 - 财政年份:2021
- 资助金额:
$ 10.83万 - 项目类别:
Collaboration in Regulatory Systems Strengthening and Standardization Activities to Increase Global Access to Safe and Effective Biological Products.
加强监管系统和标准化活动方面的合作,以增加全球获得安全有效的生物产品的机会。
- 批准号:
10491861 - 财政年份:2021
- 资助金额:
$ 10.83万 - 项目类别:
Collaboration in Regulatory Systems Strengthening and Standardization Activities to Increase Global Access to Safe and Effective Biological Products.
加强监管系统和标准化活动方面的合作,以增加全球获得安全有效的生物产品的机会。
- 批准号:
10675535 - 财政年份:2021
- 资助金额:
$ 10.83万 - 项目类别:
EPSRC Centre for Doctoral Training in Bioprocess Engineering Leadership (Complex Biological Products Manufacture)
EPSRC 生物过程工程领导力博士培训中心(复杂生物制品制造)
- 批准号:
EP/S021868/1 - 财政年份:2019
- 资助金额:
$ 10.83万 - 项目类别:
Training Grant
Exploring interactions and benefits of novel microbial biological products in blueberry propagation
探索新型微生物生物制品在蓝莓繁殖中的相互作用和益处
- 批准号:
529840-2018 - 财政年份:2018
- 资助金额:
$ 10.83万 - 项目类别:
Applied Research and Development Grants - Level 1
GOALI: Collaborative Research: Industrial Implementation of Smart Biopolymers for Purification of Biological Products
目标:合作研究:用于生物制品纯化的智能生物聚合物的工业实施
- 批准号:
1403724 - 财政年份:2014
- 资助金额:
$ 10.83万 - 项目类别:
Standard Grant
GOALI: Collaborative Research: Industrial Implementation of Smart Biopolymers for Purification of Biological Products
目标:合作研究:用于生物制品纯化的智能生物聚合物的工业实施
- 批准号:
1403697 - 财政年份:2014
- 资助金额:
$ 10.83万 - 项目类别:
Standard Grant
Formulation and delivery approaches for water soluble biological products delivered through the skin focussing on L-Ascorbic Acid.
通过皮肤输送的水溶性生物产品的配方和输送方法,重点是 L-抗坏血酸。
- 批准号:
131690 - 财政年份:2014
- 资助金额:
$ 10.83万 - 项目类别:
Feasibility Studies
Formulation and stability of biological products for skin delivery focussing on Retinol.
以视黄醇为重点的皮肤输送生物制品的配方和稳定性。
- 批准号:
131338 - 财政年份:2013
- 资助金额:
$ 10.83万 - 项目类别:
Feasibility Studies
Demonstrate the effectiveness of antimicrobial protection of new types of Biological Products
展示新型生物制品抗菌保护的有效性
- 批准号:
429734-2011 - 财政年份:2012
- 资助金额:
$ 10.83万 - 项目类别:
Experience Awards (previously Industrial Undergraduate Student Research Awards)