EXERCISE AND CALCIUM EFFECT ON THE GROWING BONE

运动和钙对骨骼生长的影响

• 批准号: 2889531
• 负责人: CHARLOTTE F SANBORN
• 金额: $ 12.22万
• 依托单位: TEXAS WOMAN'S UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-04-01 至 2002-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2889531
• 关键词: body composition; bone development; bone imaging /visualization /scanning; bone metabolism; child (0-11); child physical development; clinical research; dairy products; dietary calcium; dietary supplements; disease /disorder prevention /control; exercise; human subject; nutrition related tag; osteoporosis

DESCRIPTION (Adapted from applicant's description): The prevention of osteoporosis is dependent upon maximizing peak bone mass and minimizing subsequent bone loss. During childhood and adolescence, the goal is to increase peak bone mass. The purpose of the study is to investigate the influence of skeletal loading and calcium supplementation with dairy products on bone mineral accretion in the prepubescent skeleton. Fourth grade girls and boys will be selected from two elementary schools. Each school has 4-5 classes per grade with 80-125 children per grade level. The interventions will span two 8-month blocks in a 20-month period and will be conducted in two phases. Phase 1 will be skeletal loading and control groups. Phase 2 will be skeletal loading plus calcium intervention and calcium intervention only groups. The skeletal loading intervention program will include a variety of skipping and box jumping activities designed to stimulate bone formation. A progressive program, to a maximum of fifteen minutes, of jumping activities will be incorporated into the physical education classes that meet twice a week. The dietary groups will be instructed to supplement their diets with dairy products to 1,200 mg/day. The inclusion criteria for the subjects will be: prepubescent, non-smokers, no orthopedic problems, and absence of previous history of metabolic diseases or therapies that may affect bone metabolism. The following data will be gathered at 0, 8, and 20 months: dietary records, calcium & physical activity histories, bone scans, body composition, and Tanner stage. The primary objective is to investigate the effect of an elementary school-based jump rope and calcium intervention program on bone accrual at the lumbar spine, the proximal femur and for the total body in a group of prepubertal boys and girls. A secondary objective is to compare the bone mineral accretion of U.S. children to Canadian children undergoing a similar skeletal loading protocol.

描述（改编自申请人的描述）：预防 骨质疏松症依赖于最大化峰值骨量和最小化 随后的骨质流失。 在童年和青春期，目标是 增加峰值骨量。 本研究的目的是调查 乳制品对骨骼负荷和钙补充影响 产品对骨矿物质的增长在青春期前的骨骼。 四 将从两所小学中选出五年级的男女生。 每个 学校每个年级有4-5个班，每个年级有80-125名儿童。 的 干预措施将在20个月内跨越两个8个月的区块， 分两个阶段进行。 第一阶段是骨骼负荷和控制 组 第二阶段是骨骼负荷加钙干预， 单纯钙干预组。 骨骼负荷干预计划 将包括各种跳绳和跳箱活动，旨在 刺激骨形成。 一个渐进的程序，最多十五个 分钟，跳跃活动将被纳入身体 每周两次的教育课程。 饮食组将是 指示他们的饮食补充乳制品到1,200毫克/天。 受试者的入选标准为：青春期前、不吸烟者， 无骨科问题，无既往代谢性疾病史 可能影响骨代谢的疾病或治疗。 以下数据 将在0、8和20个月时收集：饮食记录、钙和 身体活动史、骨扫描、身体成分和坦纳分期。 主要目的是研究一个基本的 以学校为基础的跳绳和钙干预计划对骨骼增长的影响 腰椎，股骨近端和全身的一组， 青春期前的男孩和女孩 次要目的是比较骨骼 矿物质积累的美国儿童加拿大儿童经历了类似的 骨骼加载方案。