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CEREBRAL GLUTAMATE CONTROL BY IN VIVO 15N MR

CEREBRAL GLUTAMATE CONTROL BY IN VIVO 15N MR
通过体内 15N MR 控制大脑谷氨酸
批准号：
2891791
负责人：
BRIAN David ROSS
金额：
$20.53万
依托单位：
HUNTINGTON MEDICAL RESEARCH INSTITUTES
依托单位国家：
美国
项目类别：
财政年份：
1994
资助国家：
美国
项目状态：
已结题
起止时间：
1994-08-01 至 2001-05-31
来源：
https://reporter.nih.gov/project-details/2891791
关键词：
aminoacid metabolism ammonia antisense nucleic acid astrocytes brain metabolism gas chromatography mass spectrometry glutamate transporter glutamates glutamine high performance liquid chromatography hormone therapy laboratory rat neurons neurotransmitter metabolism neurotransmitter transport nitrogen metabolism nuclear magnetic resonance spectroscopy potassium ion steroids

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英文摘要
DESCRIPTION: The theme of this application is that 13C and 15N NMR, including indirect detection methods, will be used to quantify the rates of glutamate and glutamine release and uptake in the rat brain in vivo. Studies will also be performed under selected conditions which were chosen for possible clinical relevance: hyperammonemia, steroid therapy, and after inhibition of the glutarnate transporter by an antisense oligonucleotide.
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SIRT5/ammonia信号通路介导适应性自噬在急性心肌梗死中的作用及其机制研究
  • 批准号：
    81900312
  • 项目类别：
    青年科学基金项目
  • 资助金额：
    20.0万元
  • 批准年份：
    2019
  • 负责人：
    汪芸玏
  • 依托单位：
    南京医科大学