课题基金 / 基金详情

GENETIC ELEMENTS REGULATING MYELIN GENE EXPRESSION

GENETIC ELEMENTS REGULATING MYELIN GENE EXPRESSION
调节髓磷脂基因表达的遗传元件
批准号：
2891929
负责人：
ANTHONY T CAMPAGNONI
金额：
$24.93万
依托单位：
UNIVERSITY OF CALIFORNIA LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
1994
资助国家：
美国
项目状态：
已结题
起止时间：
1994-07-01 至 2002-05-31
来源：
https://reporter.nih.gov/project-details/2891929
关键词：
RNA splicing animal genetic material tag cell differentiation developmental genetics developmental neurobiology gene induction /repression gene mutation genetic promoter element genetic regulatory element genetic transcription genetically modified animals laboratory mouse myelin basic proteins myelination neurogenetics oligodendroglia recombinant proteins reporter genes structural genes tissue /cell culture

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英文摘要
DESCRIPTION: The Golli-mbp gene encodes two families of proteins, the Golli proteins and the myelin basic proteins. The overall goal of this application is to identify the genetic regulatory elements that govern specificity in the regulation of transcription start sites for this gene in oligodendrocytes and neurons in the nervous system and in macrophages and other cells in the immune system. A part of this application is to use a promoter element, as well as transgenic mice expressing a reporter gene under its control to investigate the developmental biology of these cortical pioneer neurons and the fate of the subplate that they form.
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Golli-MBP Gene Expression in the Nervous System