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GENETIC ELEMENTS REGULATING MYELIN GENE EXPRESSION

GENETIC ELEMENTS REGULATING MYELIN GENE EXPRESSION
调节髓磷脂基因表达的遗传元件
批准号：
6393669
负责人：
ANTHONY T CAMPAGNONI
金额：
$26.46万
依托单位：
UNIVERSITY OF CALIFORNIA LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
1994
资助国家：
美国
项目状态：
已结题
起止时间：
1994-07-01 至 2002-05-31
来源：
https://reporter.nih.gov/project-details/6393669
关键词：
RNA splicing animal genetic material tag cell differentiation developmental genetics developmental neurobiology gene induction /repression gene mutation genetic promoter element genetic regulatory element genetic transcription genetically modified animals laboratory mouse myelin basic proteins myelination neurogenetics oligodendroglia recombinant proteins reporter genes structural genes tissue /cell culture

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中文摘要
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英文摘要
DESCRIPTION: The Golli-mbp gene encodes two families of proteins, the Golli proteins and the myelin basic proteins. The overall goal of this application is to identify the genetic regulatory elements that govern specificity in the regulation of transcription start sites for this gene in oligodendrocytes and neurons in the nervous system and in macrophages and other cells in the immune system. A part of this application is to use a promoter element, as well as transgenic mice expressing a reporter gene under its control to investigate the developmental biology of these cortical pioneer neurons and the fate of the subplate that they form.
期刊论文(6)
专著(0)
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会议论文
Multiple kinase pathways regulate voltage-dependent Ca2+ influx and migration in oligodendrocyte precursor cells.
DOI： 10.1523/jneurosci.5086-09.2010
发表时间： 2010-05-05
期刊： The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子： --
作者： [Paez PM, Fulton DJ, Spreur V, Handley V, Campagnoni AT]
通讯作者： Campagnoni AT
Classical 18.5-and 21.5-kDa isoforms of myelin basic protein inhibit calcium influx into oligodendroglial cells, in contrast to golli isoforms.
与GOLLI同工型相反，经典的18.5和21.5-kDa同工型抑制钙的流入少突胶质细胞。
DOI： 10.1002/jnr.22570
发表时间： 2011-04
期刊： JOURNAL OF NEUROSCIENCE RESEARCH
影响因子： 4.2
作者： [Smith, Graham S. T., Paez, Pablo M., Spreuer, Vilma, Campagnoni, Celia W., Boggs, Joan M., Campagnoni, Anthony T., Harauzi, George]
通讯作者： Harauzi, George
Myelin protein expression is increased in lymph nodes of mice with relapsing experimental autoimmune encephalomyelitis.
患有复发性实验性自身免疫性脑脊髓炎的小鼠淋巴结中髓磷脂蛋白表达增加。
DOI： --
发表时间： 1997
期刊： Journal of immunology (Baltimore, Md. : 1950)
影响因子： --
作者： [MacKenzie-Graham,AJ, Pribyl,TM, Kim,S, Porter,VR, Campagnoni,AT, Voskuhl,RR]
通讯作者： Voskuhl,RR
CORE--MOLECULAR BIOLOGY
CORE--MOLECULAR BIOLOGY
Golli-MBP Gene Expression in the Nervous System
Golli-MBP Gene Expression in the Nervous System