MEDICINAL CHEMISTRY SYNTHESIS OF POTENTIAL TREATMENT

该合同的目的是设计和合成化合物， 主要影响多巴胺能系统，或者替代可卡因， 分析其影响。 该项目应涉及综合任何 以下：多巴胺摄取抑制剂，起效速度慢于 可卡因;通过抑制作用影响多巴胺能系统的化合物 多巴胺或5-羟色胺转运体; 5-羟色胺转运体; 5-羟色胺 转运蛋白选择性可卡因类似物;多巴胺部分激动剂，和 抗激动剂;和多巴胺保留可卡因兴奋剂（化合物， 结合多巴胺转运蛋白而不抑制摄取）;和化合物 对D1和D3受体具有选择性。 项目还应提供 大规模生产和类似物合成，有前途的化合物。 的 这个项目的主要目标是为NIDA提供一个新的资源， 具有治疗可卡因滥用的潜在用途的化合物。

The purpose of this contract is to design and synthesize compounds which affect primarily dopaminergic systems and either substitute for cocaine or anatagoize its effects. The project shall involve the synthesis of any of the following: dopamine uptake inhibitors with a slower rate of onset than cocaine; compound which affect dopaminergic systems through the inhibition of dopamine or serotonin transporters; serotonin transporters; serotonin transporter selective cocaine analogs; dopamine partial agonists, and anatagonists; and dopamine sparing cocaine antagoists (Compounds that bind to the dopamine transporter without inhibiting uptake); and compound selective for D1 and D3 receptors. The project shall also provide for the scale-up production, and analog synthesis, of promissing compounds. The major goal of this project is to provide NIDA with a resource of novel compounds with potential use in the treatment of cocaine abuse.