MOLECULAR MODELING OF DOPAMINE ANTAGONISTS
MOLECULAR MODELING OF DOPAMINE ANTAGONISTS
批准号:
2765213
负责人:
金额:
$0.08万
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
起止时间:
至
中文摘要
可卡因的强化作用被认为与它的
英文摘要
Cocaine's reinforcing effects are believed to be related to its
ability to inhibit dopamine uptake. From behavioral studies, it
appears that the D1, D2, D3, (and perhaps D4) receptor subtypes are
involved in the reinforcing effects of cocaine. Selective antagonists
for these receptor subtypes might be useful in the treatment of
cocaine vs. D1 and D2, may be especially useful. Computational
studies are currently underway to aid in the design of selective D3
(and D4) antagonist compounds. We require structural data for as man
high-activity D2 and D3 compounds as possible to aid in our molecular
modeling studies. This requested starting grant will be used to
search x-ray crystallographic databases for that information.
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