INDUCTION OF MELANOMA WITH UV-A
UV-A 诱导黑色素瘤
基本信息
- 批准号:2895510
- 负责人:
- 金额:$ 22.25万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1997
- 资助国家:美国
- 起止时间:1997-07-02 至 2001-04-30
- 项目状态:已结题
- 来源:
- 关键词:DNA methylation benzanthracenes carcinogen testing gene mutation melanocyte melanoma mutagen testing mutagens neoplasm /cancer genetics opossums polymerase chain reaction radiation carcinogen radiation carcinogenesis radiation genetics skin hyperplasia skin pharmacology tumor suppressor genes ultraviolet radiation
项目摘要
The long-term objective of this research is to identify risk factors
and underlying mechanisms for the induction cutaneous melanoma in
humans. Specifically. studies outlined in this proposal will (a)
determine the effectiveness of UV-A (320-400nm) radiation in the
induction of melanoma and (b) identify a role for alterations in
tumor suppressor genes in UV-A-induced melanoma. The rationale for
these studies is that human exposure to UV-A may be increasing due
to the use of chemical sunscreens that primarily block UV-B (280-320
nm) radiation, the most efficient solar wavelengths for the
induction of erythema. Thus, the use of sunscreens may result in
increased exposure to UV-A due to extended hours spent outdoors. In
addition, in recent years, high intensity UV-A radiation sources
have replaced artificial sources of UV-B for use in tanning.
Individuals using these devices experience increased levels of UV-A
exposure. Even small increases in UV-A exposure could result in
significant increases melanoma if melanoma induction is more
efficient than the induction of erythema or non-melanoma skin cancer
these wavelengths. Studies by others with a fish model predict a
high efficiency for melanoma induction by UV-A wavelengths. Results
from studies proposed herein will be extremely valuable for (1)
evaluating the capacity sunscreens to prevent melanoma, (2)
determining the potential risk of melanoma induction associated with
the use of UV-A-emitting tanning devices, and (3) identifying
molecular mechanisms of melanoma induction. The role of UV-A
radiation in the induction of melanoma will be determined using a
South American opposum, Monodelphis domestica, that is susceptible
to the induction of cutaneous melanoma upon chronic exposure to UVR
alone. Groups of opossums will be exposed to graded doses of UV-A
three times per week for up to 104 wee Animals will be monitored to
determine (1) the time to appearance of melanocytic hyperplasia, the
putative precursor of melanoma, (2) the progression of melanocytic
hyperplasia to melanoma, and (3) the time appearance and yield of
non-melanoma skin tumors. Two-stage initiation-promotion studies
will be conducted determine the capacity of UV-A to promote the
formation of melanoma in dimethylbenzanthracene (DMBA)-initiate
skin. In addition, alterations (mutations, deletions and
methylation) in p16 and p53 tumor suppressor genes will measured in
genomic DNA from melanomas induced with UV-B, UV-A and DMBA.
Archival melanoma samples from previous UV-B and DMBA studies are
available to initiate tumor suppressor gene analysis.
这项研究的长期目标是确定风险因素
项目成果
期刊论文数量(0)
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{{ truncateString('RONALD D LEY', 18)}}的其他基金
UVR-INDUCED SYSTEMIC EFFECTS AND MELANOMA INDUCTION
紫外线引起的系统效应和黑色素瘤诱导
- 批准号:
2099091 - 财政年份:1992
- 资助金额:
$ 22.25万 - 项目类别:
UVR-INDUCED SYSTEMIC EFFECTS AND MELANOMA INDUCTION
紫外线引起的系统效应和黑色素瘤诱导
- 批准号:
3202548 - 财政年份:1992
- 资助金额:
$ 22.25万 - 项目类别:
UVR-INDUCED DNA DAMAGE AND ANGIOGENIC GROWTH FACTORS
紫外线引起的 DNA 损伤和血管生成因子
- 批准号:
3265704 - 财政年份:1992
- 资助金额:
$ 22.25万 - 项目类别:
UVR-INDUCED DNA DAMAGE AND ANGIOGENIC GROWTH FACTORS
紫外线引起的 DNA 损伤和血管生成因子
- 批准号:
2162234 - 财政年份:1992
- 资助金额:
$ 22.25万 - 项目类别:
UVR-INDUCED SYSTEMIC EFFECTS AND MELANOMA INDUCTION
紫外线引起的系统效应和黑色素瘤诱导
- 批准号:
2099092 - 财政年份:1992
- 资助金额:
$ 22.25万 - 项目类别:
UVR-INDUCED DNA DAMAGE AND ANGIOGENIC GROWTH FACTORS
紫外线引起的 DNA 损伤和血管生成因子
- 批准号:
3265705 - 财政年份:1992
- 资助金额:
$ 22.25万 - 项目类别: