CHILDRENS CANCER GROUP

本提案的目标是通过以下方式支持和加强作为儿童癌症小组（CCG）主要成员的纽约大学医学中心（NYUMC）当前和未来的活动：（1）通过以下措施改善癌症儿童的预后：a）继续增加患者参与积极CCG方案的水平，B）参与CCG战略小组和学科委员会的领导职位，以开发治疗儿童癌症的改进方法，c）合作开发NYUMC研究人员的新研究。 2)通过以下方式开发儿童癌症治疗的新方法：a）参与II期研究和新药I期研究并发挥领导作用，B）在选定的疾病实体（如脑肿瘤）中开展有可能纳入未来CCG试验的试点研究。 3)通过以下方式改善儿童癌症幸存者及其家人的生活质量：a）参与CCG长期效应研究，B）评估接受癌症治疗的儿童的生活质量问题，c）将所有符合条件的患者置于开放式支持治疗研究中，d）继续参与费城儿童医院进行的心脏干预研究。 4)通过以下方式积极参与生物学研究：a）及时完整地提交生物学样本和数据，B）NYUMC科学家和实验室参与涉及细胞遗传学、分子生物学和其他实验室学科的研究。 5)增加与NYUMC相关的附属机构网络，以便招募目前无法进行临床试验的患者进行研究。 这包括与布鲁克林医院的联系和最近与迈蒙尼德医院的联系-两者都照顾城市少数民族人口，否则不参加临床试验。

The objectives of this proposal are to support and enhance the current and future activities of New York University Medical Center (NYUMC) as a principal member of the Children's Cancer Group (CCG) by: (1) Improving the outcome for children with cancer through, a) continued patient entries at an increasing level to active CCG protocols, b) participation in leadership positions on CCG Strategy Groups and Discipline Committees so as to develop improved methods of treating childhood cancer, c) collaborating in the development of new studies by NYUMC investigators. 2) Developing new methodologies for the treatment of childhood cancer by, a) participation and leadership roles in Phase II studies and New Agent Phase I studies, b) piloting studies that have potential for incorporation into future CCG trials in selected disease entities such as brain tumors. 3) Improving the quality of life for survivors of childhood cancer and their families by, a) participating in CCG long-term effects studies, b) evaluating quality of life issues in children being treated for cancer, c) placing all eligible patients on open supportive care studies, d) continued participation in the cardiac intervention study conducted by the Children's Hospital of Philadelphia. 4) Active participation in biology studies by, a) timely and complete submission of biology samples and data, b) participation of NYUMC scientists and laboratories in studies involving cytogenetics, molecular biology and other laboratory disciplines. 5) Increasing the network of affiliated institutions relating to NYUMC so as to recruit patients for study who are currently not available for clinical trials. This includes the affiliation with Brooklyn Hospital and the recent affiliation with Maimonides Hospital- both caring for urban minority populations not otherwise participating in clinical trials.