CHILDRENS CANCER GROUP

儿童癌症组

• 批准号: 6124652
• 负责人: AARON R RAUSEN
• 金额: $ 9.27万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-06-10 至 2002-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6124652
• 关键词: acute lymphocytic leukemia; acute myelogenous leukemia; antineoplastics; bone marrow transplantation; bone neoplasms; brain neoplasms; clinical research; clinical trials; combination cancer therapy; combination chemotherapy; cooperative study; cytogenetics; data management; human subject; human therapy evaluation; liver neoplasms; lymphoma; molecular oncology; neoplasm /cancer chemotherapy; neoplasm /cancer diagnosis; neoplasm /cancer epidemiology; neoplasm /cancer immunotherapy; neoplasm /cancer pharmacology; neoplasm /cancer radiation therapy; neoplasm /cancer surgery; neuroblastoma; oncology nursing; pediatric neoplasm /cancer; statistics /biometry; tissue resource /registry

The objectives of this proposal are to support and enhance the current and future activities of New York University Medical Center (NYUMC) as a principal member of the Children's Cancer Group (CCG) by: (1) Improving the outcome for children with cancer through, a) continued patient entries at an increasing level to active CCG protocols, b) participation in leadership positions on CCG Strategy Groups and Discipline Committees so as to develop improved methods of treating childhood cancer, c) collaborating in the development of new studies by NYUMC investigators. 2) Developing new methodologies for the treatment of childhood cancer by, a) participation and leadership roles in Phase II studies and New Agent Phase I studies, b) piloting studies that have potential for incorporation into future CCG trials in selected disease entities such as brain tumors. 3) Improving the quality of life for survivors of childhood cancer and their families by, a) participating in CCG long-term effects studies, b) evaluating quality of life issues in children being treated for cancer, c) placing all eligible patients on open supportive care studies, d) continued participation in the cardiac intervention study conducted by the Children's Hospital of Philadelphia. 4) Active participation in biology studies by, a) timely and complete submission of biology samples and data, b) participation of NYUMC scientists and laboratories in studies involving cytogenetics, molecular biology and other laboratory disciplines. 5) Increasing the network of affiliated institutions relating to NYUMC so as to recruit patients for study who are currently not available for clinical trials. This includes the affiliation with Brooklyn Hospital and the recent affiliation with Maimonides Hospital- both caring for urban minority populations not otherwise participating in clinical trials.

该提案的目标是通过以下方式支持和加强纽约大学医学中心 (NYUMC) 作为儿童癌症小组 (CCG) 主要成员的当前和未来活动：(1) 通过以下方式改善癌症儿童的治疗结果：a) 继续增加患者参与积极的 CCG 方案，b) 参与 CCG 战略小组和学科委员会的领导职位，以开发治疗儿童癌症的改进方法，c) 与 NYUMC 研究人员合作开展新研究。 2) 通过以下方式开发治疗儿童癌症的新方法：a) 在 II 期研究和新药 I 期研究中发挥参与和领导作用，b) 试点研究有可能纳入未来针对选定疾病实体（如脑肿瘤）的 CCG 试验。 3) 通过以下方式改善儿童癌症幸存者及其家人的生活质量：a) 参与 CCG 长期影响研究，b) 评估接受癌症治疗的儿童的生活质量问题，c) 让所有符合条件的患者接受开放支持性护理研究，d) 继续参与费城儿童医院开展的心脏干预研究。 4) 积极参与生物学研究，a) 及时完整地提交生物学样本和数据，b) NYUMC 科学家和实验室参与涉及细胞遗传学、分子生物学和其他实验室学科的研究。 5) 扩大NYUMC相关附属机构网络，以招募目前无法参加临床试验的患者进行研究。 这包括与布鲁克林医院的附属关系以及最近与迈蒙尼德医院的附属关系——两者都照顾不参加临床试验的城市少数群体。