CELL ASSEMBLIES, PHASE SEQUENCES AND MEMORY DYNAMICS

描述（改编自申请人的摘要）：这是一个应用程序， a K 05高级科学家奖。 在他的职业生涯中，候选人 研究记忆的神经生物学和计算基础。 末 20世纪70年代，他为生物学实现提供了第一个证据， 赫布的联想记忆的神经生理学假设，通过显示， 海马突触长时程增强（LTP）涉及 融合投入的合作。 从那以后，他做了许多 有助于理解LTP的过程中，在生物物理 和行为水平，并作出了重大贡献， 神经网络理论的记忆和神经编码的空间 认知地图（Cognitive Maps） 因为记忆是 神经群体的特性，由增强的相互连接支持， 候选人指导了目前常规方法的开发， 能够同时记录超过100个神经元的自由行为， 啮齿动物。 这种方法为神经元研究打开了一扇前所未有的窗口， 相互作用，并提供了强有力的间接证据， Hebb的“细胞组装”和“相序列”在离线过程中 海马体和新皮层对近期记忆的再加工。 的 候选人目前是神经系统，记忆， 和老龄化，在亚利桑那大学，一个9,000平方米。 英尺 研究设施 致力于记忆研究 该设施包括专门的外科手术， 神经解剖学和电子工程套件，以及几个专门 为行为神经生理学设计了受控环境 的 候选人自己的研究团队包括5名博士后，6名研究生，4名 本科研究助理，5电子，计算机，和 神经生理学研究专家 候选人的即时和长期 长期研究的目标是了解大脑动力学的基础， 将情景记忆转化为分类知识的过程 也就是记忆巩固 具体的职业发展计划 该奖项支持的是开始开发技术， 记录了大脑皮层和海马体中多达400个细胞， 行为灵长类动物，并开发新的分析工具，以了解 就这些记录的大量细胞而言，细胞聚集体的行为 单位 具体的研究项目涉及的问题 睡眠期间记忆痕迹的重新激活，这是如何由 海马体，以及这个过程本身是否真的是行为的， 意义

DESCRIPTION (Adapted from applicant's abstract): This is an application for a K05, Senior Scientist Award. Throughout his career, the candidate has pursued the neurobiological and computational basis of memory. In the late 1970's, he provided the first evidence for the biological realization of Hebb's neurophysiological postulate for associative memory, by showing that synaptic long-term potentiation (LTP) in the hippocampus involved the cooperation of converging inputs. Since then, he has made numerous contributions to understanding the process of LTP at both the biophysical and behavioral levels, and contributed significantly to the development of neural network theories of both memory and the neural encoding of spatial information (cognitive maps). Motivated by the idea that memories are properties of neural populations, supported by enhanced mutual connections, the candidate has guided the development of methods that currently routinely enable recording simultaneously from over 100 neurons in the freely behaving rodent. This method has opened an unprecedented window on neuron interactions and has provided strong indirect evidence for the existence of Hebb's "cell assemblies" and "phase sequences" during a process of off-line reprocessing of recent memories in the hippocampus and neocortex. The candidate is currently Director of the Division of Neural Systems, Memory, and Aging, at the University of Arizona, a 9,000 sq. ft. research facility dedicated to memory research. The facility includes dedicated surgical, neuroanatomical and electronics engineering suites, and several specially designed controlled environments for behavioral neurophysiology. The candidate's own research team includes 5 postdoctoral, 6 graduate, and 4 undergraduate research associates, and 5 electronics, computer, and neurophysiological research specialists. The candidate's immediate and long term research goal is to understand the brain dynamics underlying the transformation of episodic memory into categorical knowledge, a process known as memory consolidation. The specific career development plan to be supported by this award is to begin to develop the technology to enable recording from up to 400 cells from the cortex and hippocampus in the behaving primate and to develop new analytical tools for understanding the behavior of cell assemblies in terms of these large populations of recorded units. The specific research projects deal with the questions of the reactivation of memory traces during sleep, how this is orchestrated by the hippocampus, and whether the process itself is truly of behavioral significance.