CELL ASSEMBLIES, PHASE SEQUENCES AND MEMORY DYNAMICS

描述(改编自申请人摘要)：这是一份申请 A K05，高级科学家奖。在他的职业生涯中，这位候选人 探索记忆的神经生物学和计算基础。在晚间 20世纪70年代的S，他提供了第一个证据，证明了 Hebb关于联想记忆的神经生理学假设，通过证明 海马区突触长时程增强(LTP)涉及 汇聚投入的合作。从那时起，他已经做出了许多 对理解LTP过程的生物物理贡献 和行为水平，并对发展做出了重大贡献 空间记忆和神经编码的神经网络理论 信息(认知图)。其动机是记忆是 在增强的相互连接的支持下，神经群体的特性， 候选人指导了目前例行的方法的开发 允许同时记录来自100多个神经元的自由行为 啮齿动物。这种方法为神经元的研究打开了一扇前所未有的窗 并提供了强有力的间接证据，证明了 Hebb脱机过程中的“细胞组装”和“相序” 海马区和大脑皮层新近记忆的再处理。这个 候选人目前是神经系统、记忆、 以及亚利桑那大学的Aging，面积为9000平方米。英国《金融时报》研究设施 致力于记忆研究。该设施包括专门的外科手术， 神经解剖学和电子工程套件，以及几个专门的 为行为神经生理学设计受控环境。这个 考生自己的研究团队包括5名博士后，6名研究生和4名 本科生助理研究员，以及5名电子、计算机和 神经生理学研究专家。候选人的直接和长期的 学期研究的目标是了解隐藏在大脑中的 情景记忆向范畴知识的转化是一个过程 这被称为记忆巩固。具体的职业发展计划是 由该奖项支持的是开始开发技术以使 记录来自大脑皮质和海马区的多达400个细胞 并开发新的分析工具来理解 根据记录的这些大种群的细胞组件的行为 单位。具体的研究项目涉及的问题是 在睡眠期间重新激活记忆痕迹，这是如何由 海马体，以及这一过程本身是否真的是行为 意义。

DESCRIPTION (Adapted from applicant's abstract): This is an application for a K05, Senior Scientist Award. Throughout his career, the candidate has pursued the neurobiological and computational basis of memory. In the late 1970's, he provided the first evidence for the biological realization of Hebb's neurophysiological postulate for associative memory, by showing that synaptic long-term potentiation (LTP) in the hippocampus involved the cooperation of converging inputs. Since then, he has made numerous contributions to understanding the process of LTP at both the biophysical and behavioral levels, and contributed significantly to the development of neural network theories of both memory and the neural encoding of spatial information (cognitive maps). Motivated by the idea that memories are properties of neural populations, supported by enhanced mutual connections, the candidate has guided the development of methods that currently routinely enable recording simultaneously from over 100 neurons in the freely behaving rodent. This method has opened an unprecedented window on neuron interactions and has provided strong indirect evidence for the existence of Hebb's "cell assemblies" and "phase sequences" during a process of off-line reprocessing of recent memories in the hippocampus and neocortex. The candidate is currently Director of the Division of Neural Systems, Memory, and Aging, at the University of Arizona, a 9,000 sq. ft. research facility dedicated to memory research. The facility includes dedicated surgical, neuroanatomical and electronics engineering suites, and several specially designed controlled environments for behavioral neurophysiology. The candidate's own research team includes 5 postdoctoral, 6 graduate, and 4 undergraduate research associates, and 5 electronics, computer, and neurophysiological research specialists. The candidate's immediate and long term research goal is to understand the brain dynamics underlying the transformation of episodic memory into categorical knowledge, a process known as memory consolidation. The specific career development plan to be supported by this award is to begin to develop the technology to enable recording from up to 400 cells from the cortex and hippocampus in the behaving primate and to develop new analytical tools for understanding the behavior of cell assemblies in terms of these large populations of recorded units. The specific research projects deal with the questions of the reactivation of memory traces during sleep, how this is orchestrated by the hippocampus, and whether the process itself is truly of behavioral significance.