NEUROMUSCULAR COMPARTMENTS OF LARYNGEAL MUSCLES

喉肌的神经肌肉室

• 批准号: 2837965
• 负责人: IRA SANDERS
• 金额: $ 33.27万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-12-01 至 2000-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2837965
• 关键词: adenosinetriphosphatase; afferent nerve; axon; confocal scanning microscopy; dissection; dogs; fluorescent dye /probe; histochemistry /cytochemistry; histology; human tissue; image processing; immunocytochemistry; innervation; larynx muscle; motor neurons; muscle function; myofibrils; neuroanatomy; neuromuscular system; neuroregulation; tissue /cell preparation; vocal cords; vocalization

In the report of the National Strategic Research Plan by the NIDCD, the first recommendation for research priorities in voice reads as follows: "Valuated the compartmentalization of laryngeal muscles with regard to histochemistry and motor unit organization..."(p.122). Using this recommendation as a basis, preliminary work was performed to define these compartments in the canine larynx. It was found that all muscles except the lateral cricoarytenoid. Muscle. This muscle has two lateral compartments, the vertical and oblique, which appear to cause the lateral sliding and backward rocking of the arytenoid cartilage which is seen during inspiration. The medial compartment is termed the horizontal and appears to swivel the arytenoid cartilage in order to precisely position the vocal process during phonation. It is hypothesized that most laryngeal muscles are composed of neuromuscular compartments. It is possible that these compartments are organized into two main systems: a midline phonatory system, composed of the transverse interarytenoid and the medial parts of the posterior cricoarytenoid, thyroarytenoid and cricothyroid muscles; a lateral articulatory system, composed of the oblique interarytenoid, lateral cricoarytenoid, and the lateral parts of hie posterior cricoarytenoid, thyroarytenoid and cricothyroid muscles. In the proposed study human laryngeal muscles will be examined for compartments. Neuromuscular compartments will be defined by muscle fiber orientation, fascial barriers, and patterns of their nerve supply. Specialization within compartments will be defined by the ATPase of their muscle fibers and the content and arrangement of motor and sensory axons. All muscles will be examined, however the emphasis will be placed on the thyroarytenoid, where there appears to be a large number of subcompartments which interact to control vocal cord vibration during phonation. This study is expected to have critical relevance for all aspects of neurolaryngology.

在NIDCD国家战略研究计划的报告中 语音研究重点的首先建议如下： “评估喉部肌肉的分隔 组织化学和运动单元组织...”（第122页）。使用此 建议作为基础，进行初步工作以定义这些 犬喉室。 发现除了 侧向cricarytenoid。 肌肉。 这个肌肉有两个侧面 车厢，垂直和倾斜，似乎导致侧面 芳香软骨的滑动和向后摇摆 在灵感中。 内侧室称为水平和 似乎可以旋转芳香软骨以精确位置 发声过程中的声音过程。 假设大多数喉部肌肉由 神经肌肉室。 这些隔间可能是 组织成两个主要系统：组成的中线语音系统 横向室内类固醇和后部的内侧部位 颗粒状类肌，甲状腺瘤和甲状腺功能亢进；侧面 关节系统，由倾斜的内部，侧面组成 Cricarytenoid和Hie后cricarytenoid的外侧部分， 甲状腺毒素和肠甲状腺肌肉。 在拟议的研究中，将检查人喉肌肉的 车厢。 神经肌肉室将由肌肉纤维定义 其神经供应的方向，筋膜障碍和模式。 隔室中的专业化将由其ATPase定义 肌肉纤维以及运动和感觉轴突的内容和排列。 所有肌肉都将被检查，但是重点将放在 甲状腺素，似乎有大量 在控制声带振动期间相互作用的子组门 发声。 预计这项研究对所有人都有关键的相关性 神经咽喉科的各个方面。