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ULTRASOUND APPLICATORS FOR THERMOBRACHYTHERAPY

用于热近距离治疗的超声波探头

基本信息

批准号：
2895372
负责人：
Chris John Diederich
金额：
$ 8.65万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
1995
资助国家：
美国
起止时间：
1995-07-01 至 2001-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/2895372
关键词：
biomaterial development /preparation biomaterial evaluation catheterization heat implant medical implant science monitoring device neoplasm /cancer radionuclide therapy neoplasm /cancer thermotherapy nonhuman therapy evaluation perfusion phantom model radiation dosage swine ultrasound

项目摘要

Hyperthermia has been shown to substantially increase the effectiveness of radiation and drugs in the clinical management of cancer, but the response of tumors to combined therapy is highly dependent upon the uniformity and localization of heating within the target volume. Recent studies have shown that applying the heat, and radiation concurrently will significantly improve tumor control, and is most dramatic for long duration interstitial heating with concurrent brachytherapy. The few interstitial heating technologies which are compatible for combined therapy exhibit an inability to effectively control the temperature distribution along the length of the implant, which often translates into poor heating uniformity and a low minimum thermal dose. This proposal describes a research plan to develop an interstitial heating system which will be more effective than former technologies in delivering simultaneous interstitial thermoradiotherapy to previously difficult to treat sites such as brain. This includes: l) the development of directly implantable multielement ultrasound applicators that feature dynamic control of the longitudinal power deposition and allow for the simultaneous insertion of radiation sources; 2) the development of treatment optimization and control software to preplan the stereotactic placement of applicators with respect to thermal and radiation dosimetry considerations, and regulate power levels to attain uniform temperature distributions of maximum thermal dose. The impact of this approach will be most significant for targets in brain where sparse implants and non-parallel alignment of sources are often necessary. In the future, this system may be readily adapted for use in other sites such as prostate, where advantages such as the ability to adjust the power deposition along the length of each applicator and precisely control the localization of heating are essential. The primary objectives are to produce interstitial applicators and associated planning & control programs which will provide more uniform and bigger overall thermal dose distributions than currently available interstitial heating technologies, and to facilitate the delivery of simultaneous thermoradiotherapy. The development of this heating technique will provide an improved heating modality ready for Phase I/II trials of long duration simultaneous thermoradiotherapy.

热疗已被证明可以大大提高放射和药物在癌症的临床管理，但反应肿瘤的联合治疗是高度依赖于均匀性，目标体积内的加热的局部化。最近的研究表明同时施加热量和辐射将显著改善肿瘤控制，且长期最显著持续间质加热与并行近距离放射治疗。为数不多间隙加热技术，治疗不能有效地控制温度沿着植入物的长度分布，这通常转化为加热均匀性差和最小热剂量低。该建议描述了一项研究计划，以开发一种间隙加热系统将比以前的技术更有效地提供同时间质热放疗，以前难以治疗部位如大脑。这包括：（1）直接开发具有动态特性可植入多元件超声施加器纵向功率沉积的控制，并允许同时插入辐射源; 2）开发治疗优化和控制软件，用于预先计划立体定向根据热和辐射剂量测定放置施源器考虑因素，并调节功率水平，以达到均匀的温度最大热剂量分布。这种方法的影响将是最显着的目标在大脑中其中稀疏注入和源的非平行对准通常必要在未来，该系统可以很容易地适用于其他部位，如前列腺，其中的优势，如能力，沿着每个施加器的长度调节功率沉积，精确控制加热的位置是至关重要的。主目标是生产间质施用器和相关的规划和控制程序，这将提供更统一和更大的整体热剂量分布比目前可用的间隙加热技术，并促进同时提供热放射疗法。这种加热技术的发展将提供一种改进的加热模式，可用于长期I/II期试验同步热放疗