EARLY EXPOSURE TO LEAD AND ADOLESCENT DEVELOPMENT

描述（作者摘要）：目前没有出生队列， 铅暴露对神经心理影响的前瞻性研究 青春期的社会适应和社会功能。 早期铅的作用 青少年神经心理、情感和社会发展方面的暴露 基本上是未知的。 神经心理功能缺陷，学术 成就和亲社会行为代表了一个严重的公共健康 社会经济上处于不利地位的美国城市青年的问题 States. 早期接触铅被认为会导致 智力成就和学习问题。 此外，链接 认知缺陷和反社会行为之间的联系 确立了习 因此，假设早期铅暴露将 与执行功能缺陷相关， 攻击性破坏性的同伴关系，最终 犯罪行为的发生率/普遍程度。 一个前瞻性的方法将是 用于评估产前和产后早期的长期影响 铅暴露对神经心理缺陷发展的影响（靶向 已知受铅影响的功能以及区分人群 青少年犯罪与非犯罪青少年之间的差异），同伴关系中的困难 （利用创新的课堂社交和同行提名 方法学），人格障碍（使用标准化的测量方法， 人格和自我概念），以及家庭、学校中的反社会行为 和整个社区（利用父母/监护人提供信息和自我 报告）。 对约300例受试者的出生队列进行了随访 自1980年以来，定期评估血铅浓度， 乳牙铅浓度，健康史，社会遗传因素， 和神经行为发育。

DESCRIPTION (Author's Abstract): There are currently no birth cohort, prospective studies of the impact of lead exposure on neuropsychological functioning and social adjustment in adolescence. The role of early lead exposure in adolescent neuropsychological, emotional and social development is largely unknown. Deficits in neuropsychological functioning, academic achievement, and prosocial behavior represent a serious public health problem for socioeconomically disadvantaged, inner-city youth in the United States. Early exposure to lead is believed to result in reduced intellectual attainment and learning problems. Furthermore, the link between cognitive deficits and antisocial behavior has been well established. Therefore, it is hypothesized that early lead exposure will be associated with deficits in executive function, an increase in aggressive-disruptive peer relationships, and ultimately a higher incidence/prevalence of delinquent acts. A prospective methodology will be employed to assess the long-range effects of prenatal and early postnatal lead exposure on the development of neuropsychological deficits (targeting functions known to be affected by lead as well as distinguishing populations of delinquent from non-delinquent youth), difficulties in peer relationships (utilizing innovative classroom sociometric and peer nomination methodologies), personality disturbances (utilizing standardized measures of personality and self-concept), and antisocial behavior in the home, school and community at large (utilizing parental/guardian informants and self reports). This birth cohort of approximately 300 subjects has been followed since 1980 with regularly scheduled assessments of blood lead concentration, deciduous tooth lead concentration, health history, sociohereditary factors, and neurobehavioral development.