GENETIC STRUCTURE OF CHAGAS DISEASE VECTOR--GUATEMALA

南美锥虫病载体的遗传结构——危地马拉

• 批准号: 2879849
• 负责人: PATRICIA L DORN
• 金额: $ 8.95万
• 依托单位: LOYOLA UNIVERSITY IN NEW ORLEANS
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-08-01 至 2003-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2879849
• 关键词: Guatemala; Insecta; Trypanosoma cruzi; alleles; animal population genetics; arthropod borne communicable disease; communicable disease control; disease vectors; gene expression; gene frequency; genetic markers; insect control; polymerase chain reaction; trypanosomiasis

DESCRIPTION (Adapted from the Applicant's Abstract): Chagas disease, caused by the parasite Trypanosoma cruzi, is a leading cause of heart disease in Latin America. The parasite is transmitted to humans and animals in the feces of triatomine vectors. Effective drugs (beyond the initial acute phase of the disease) or vaccines are not available. However, recent efforts at controlling the vectors in South America have effectively blocked transmission of Chagas in several countries. These control efforts were aided by knowledge of the population genetics of the vector. Triatoma dimidiata and Rhodnius prolixus are the two most important Chagas vectors in Guatemala. Triatoma dimidiata is of special concern for control efforts since it is widespread in Guatemala and its presence in both sylvatic and domestic habitats means it can re-colonize fumigated houses from sylvatic reservoirs. Despite its importance as a Chagas vector, nothing is known about the population genetics of Triatoma dimidiata. An understanding of the population genetics would reveal rates of migration, breeding structure and gene flow and possibly genetic differences between vector subpopulations. These studies will provide information essential to designing effective vector control strategies to interrupt transmission of this parasite and thus reduce the incidence of heart disease in Latin America.

描述（改编自申请人摘要）：恰加斯病，由

项目成果

Two distinct Triatoma dimidiata (Latreille, 1811) taxa are found in sympatry in Guatemala and Mexico.

• DOI: 10.1371/journal.pntd.0000393
• 发表时间: 2009
• 期刊: PLoS neglected tropical diseases
• 影响因子: 3.8
• 作者: Dorn PL;Calderon C;Melgar S;Moguel B;Solorzano E;Dumonteil E;Rodas A;de la Rua N;Garnica R;Monroy C
• 通讯作者: Monroy C