MOLECULAR BIOLOGY OF CHROMOSOME 21 AND DOWN SYNDROME

这次研讨会定于1999年6月6日至10日在贝特加布里埃尔举行 以色列的文化中心。 研讨会的目的是 与具有广泛研究兴趣的研究人员一起， 讨论关于唐氏综合症和人类的知识现状 21号染色体。 研究视角旨在涵盖所有 生物学、分子生物学和医学的相关领域， 有助于加深我们对导致全球化的机制的理解， DS的表型。 对这里提议的讲习班的需要是从巨大的 大量新的分子生物学数据， 人类基因组计划的结果。 具体 21q的完整基因组测序正在进行中， 来自日本、德国和美国的实验室。 几 兆兆已经完成，整个21季度是 预计将在1999年举行本次会议时完成。 作为 测序数据积累，额外的新基因及其完整的 将识别编码序列。 表达分析和蛋白质 功能决定将迅速发展，并伴随着。 预计讲习班的形式将促进各部门之间的互动， 学科，有助于集中和重新定向研究工作，以最大限度地利用 开发数据，并建立新的合作和渠道， 调查

This workshop is scheduled to be held June 6-10, 1999 at the Bet Gabriel Cultural Center in Israel. The objective of the workshop is to bring together investigators with a broad spectrum of research interests to discuss the current state of knowledge regarding Down Syndrome and human chromosome 21. Research perspectives are designed to encompass all relevant areas of biology, molecular biology and medicine as they pertain to increasing our understanding of the mechanisms leading to the phenotype of DS. The need for the workshop proposed here has grown from the enormous amount of new molecular, biological data that has developed for chromosome 21 as a result of the human genome initiative. Specifically complete genomic sequencing of 21q is in progress in a consortium of laboratories from Japan, Germany and the United States. Several megabases have already been completed and the entirety of 21q is projected to be completed by the time of this meeting 1999. As sequencing data accumulate, additional new genes and their complete coding sequences will be identified. Expression analyses and protein functional determinations will develop rapidly and concomitantly. It is anticipated that a workshop format will foster interaction across disciplines, help to focus and redirect research efforts for maximal use of developing data, and establish new collaborations and avenues of investigation.