GORDON CONFERENCE ON MAMMALIAN DNA REPAIR, 1999

需要资金使科学家能够参加第七届 每两年举行一次的哺乳动物DNA修复戈登研究会议 1999年2月7日至2月12日，加利福尼亚州文图拉。选定的演讲者是 目前DNA修复和相关细胞领域的领先者 流程。除了为这些专家提供一个论坛来介绍他们的 最新的成果和想法，会议将促进广泛的 通过全体讨论在所有与会者之间进行广泛的互动 会议和海报上。精选海报推荐人(一般为学生 和年轻的科学家)将有机会突出他们的 在简短的陈述中的研究结果，以激发下面的辩论 全体会谈。(几张幻灯片，但没有幻灯片 允许参加这些“讨论点”)。会议通常是 超额认购，出席人数限制为135人。这个 与会者将从全球的大学、研究机构中挑选出来 研究所、政府和工业研究实验室。尽一切努力 将选择一个平衡的个人组合，范围从 将哺乳动物DNA修复方面的领先带给新进入该领域的年轻科学家。 将采取协调一致的努力，寻找和吸引合格的 少数民族科学家参加了会议。 1999年会议与上届会议的不同之处在于，它将重点放在 更狭隘地研究哺乳动物系统。这反映了爆炸性的增长 DNA修复领域和令人兴奋的、连接DNA修复的新数据 人类遗传性疾病和癌症(例如BRCA基因突变 乳腺癌的易感性似乎在DNA修复中起着作用)。 第一次会议将由理查德·塞特洛博士发表主旨演讲 和另外两个特别讲座，由Jacqueline Barton教授和Dr。 托马斯·林达尔。以下八个会议将确定以下领域 令人兴奋的新信息正在涌现，但专家们可能会对此意见不一。 会议主题包括：内源性损伤的修复，在核和 线粒体；错配的跨损伤合成和修复；DNA修复 酶结构和底物相互作用；核苷酸切除修复- 转录的作用；碱基切除修复-与其他 通路；诱导反应和细胞周期检查点；细胞 修复的定位和结合蛋白的作用；以及DNA修复 人类遗传病中的缺陷。 总之，本次会议将把DNA修复作为一个关键组成部分进行审查 在基因组监测中，这对整体完整性是如此关键 和哺乳动物细胞的功能。最近的发现使DNA 在基础研究中处于举足轻重的地位 肿瘤学、老年学、环境健康和发育生物学。我们 希望突出最有前途和最令人兴奋的研究途径 在这次会议上的热烈讨论中。

Funds are requested to enable scientists to participate in the seventh bi-annual Gordon Research Conference on Mammalian DNA Repair, to be held in Ventura, CA, Feb. 7- Feb. 12, 1999. The selected speakers are current leaders in the fields of DNA repair and related cellular processes. Besides providing a forum for these experts to present their most recent results and ideas, the conference will facilitate wide- ranging interactions among all attendees through Plenary Discussion Sessions and at posters. Selected poster presenters (generally students and younger scientists) will be given the opportunity to highlight their research results in short presentations, to stimulate debate following the plenary talks. (Several overhead transparencies, but no slides will be permitted for these "Discussion Points"). The Conference is normally oversubscribed with attendance limited to 135 participants. The attendees will be chosen globally from universities, research institutes, and government and industrial research labs. Every effort will be made to select a well-balanced mix of individuals ranging from leads in mammalian DNA repair to younger scientists new to the filed. A concerted attempt will be made to identify and attract qualified minority scientists to the conference. The 1999 Conference differs from the previous one, in that it will focus more narrowly on mammalian systems. This reflects the explosive growth of the DNA repair field and the exciting, new data linking DNA repair to human genetic disease and cancer (e.g. BRCA gene mutations that predispose to breast cancer appear to have roles in DNA repair). The first session will feature a keynote address by Dr. Richard Setlow and two other special lectures, by Prof. Jacqueline Barton and by Dr. Thomas Lindahl. The following eight sessions will define areas in which exciting new information is emerging but in which experts may disagree. The session topics include: Repair of endogenous damage, in nuclei and mitochondria; Translesion synthesis and repair of mismatches; DNA repair enzyme structure and substrate interactions; Nucleotide excision repair- role of transcription; Base excision repair- overlap with other pathways; Inducible responses and cell cycle checkpoints; Cellular localization of repair and effects of bound proteins; and DNA repair deficiency in human genetic disease. In summary, this Conference will examine DNA repair as a key component in the genomic surveillance that is so crucial to the overall integrity and function of mammalian cells. Recent discoveries have catapulted DNA repair into a pivotal position in fundamental research in the fields of oncology, aging, environmental health, and developmental biology. We hope to highlight the most promising and exciting avenues of research in robust discussions at this conference.