STEROID CONTROL OF CENTRAL OXYTOCIN RELEASE

中枢催产素释放的类固醇控制

• 批准号: 6228465
• 负责人: JACK D CALDWELL
• 金额: $ 5.06万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-05-04 至 2001-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6228465
• 关键词: Animalia; G protein; calcium channel; diethylstilbestrol; dosage; estradiol; globulins; hormone regulation /control mechanism; hypothalamus; oxytocin; preoptic areas; stereoisomer; steroid hormone receptor

DESCRIPTION (Adapted from the applicant's Abstract): Estradiol 17b (E) acts centrally to influence both reproduction and behaviors in mammals, and the neuropeptide oxytocin (OT) is important in coordination of ovulation with mating behaviors. Two areas of the brain, medial preoptic area (MPOA) and medial basal hypothalamus (MBH), have important roles in this coordination. Dr. Caldwell has observed that E conjugated at position 6 to bovine serum albumen (E-6-BSA) stimulated OT release from anuclear homogenates of the MPOA and MBH. The present studies will examine whether E-6-BSA stimulates OT release by acting on a membrane/cytoplasmic E receptor or on a novel receptor for sex hormone binding globulin. Both undergraduate and graduate students will participate in the research.

描述（改编自申请人的摘要）：雌二醇17b（e）行为 集中影响哺乳动物的生殖和行为，以及 神经肽催产素（OT）对于与排卵的协调很重要 交配行为。 大脑的两个区域，内侧前区域（MPOA）和 内侧下丘脑（MBH）在这种协调中具有重要作用。 Caldwell博士观察到E在牛血清的位置6偶联 蛋白（E-6-BSA）刺激了OT释放的OT释放 MPOA和MBH。 本研究将检查E-6-BSA是否刺激 OT通过在膜/细胞质E受体或新颖的释放中释放 性激素结合球蛋白的受体。 本科和毕业生 学生将参加研究。

项目成果

Sex hormone binding globulin stimulates female sexual receptivity.

性激素结合球蛋白刺激女性性接受能力。

• DOI: 10.1016/s0006-8993(00)02569-5
• 发表时间: 2000
• 期刊: Brain research
• 影响因子: 2.9
• 作者: Caldwell,JD;Moe,BD;Hoang,J;Nguyen,T
• 通讯作者: Nguyen,T

Evidence of sex hormone binding globulin binding sites in the medial preoptic area and hypothalamus.

内侧视前区和下丘脑中性激素结合球蛋白结合位点的证据。

• DOI: 10.1055/s-2001-12618
• 发表时间: 2001
• 期刊: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme
• 作者: Caldwell,JD