PROTEIN Z DEPENDENT PROTEINASE INHIBITOR

蛋白质 Z 依赖性蛋白酶抑制剂

• 批准号: 6056546
• 负责人: GEORGE J BROZE
• 金额: $ 32.24万
• 依托单位: BARNES-JEWISH HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-08 至 2002-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6056546
• 关键词: antithrombin III; blood chemistry; blood coagulation; blood proteins; coagulation factor X; complementary DNA; human subject; immunologic assay /test; laboratory mouse; laboratory rabbit; monoclonal antibody; phlebotomy; phospholipids; protease inhibitor; protein binding; protein purification; protein sequence; protein structure function; thromboplastin; vitamin K

DESCRIPTION: (Investigator's abstract) Protein Z is a vitamin K-dependent plasma protein of previously unknown function. The goals of this proposal are to biochemically characterize: 1) the interaction between protein Z and factor Xa at the surface of phospholipids; 2) the protein mediated enhancement of factor Xa inhibition by tissue factor pathway inhibitor; and 3) the protein Z-dependent inhibition of factor Xa produced by an additional, previously unrecognized plasma protein. In additional studies, the in vivo consequences of protein Z deficiency will be determined in mice. The experiments are designed to provide information, now lacking, concerning the function of protein Z. These results should enhance our understanding of both hemostasis and pathological thromboembolism.

描述：(研究人员摘要)蛋白质Z是一种依赖维生素K的物质 以前未知功能的血浆蛋白。这项提案的目标是 生化特征：1)蛋白质Z与蛋白质Z之间的相互作用 磷脂表面的Xa因子；2)蛋白质介导 组织因子途径抑制物对Xa因子抑制作用的增强 3)An产生的Xa因子的蛋白Z依赖性抑制 另外，以前未被识别的血浆蛋白。在其他研究中， 蛋白质Z缺乏的体内后果将在小鼠身上确定。 这些实验旨在提供目前缺乏的关于以下方面的信息 这些结果有助于我们更好地理解蛋白质Z的功能。 止血和病理性血栓栓塞症。