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DIETARY FAT AND THE OXIDATION OF PLAQUE LIPIDS

DIETARY FAT AND THE OXIDATION OF PLAQUE LIPIDS
膳食脂肪和斑块脂质的氧化
批准号：
6044024
负责人：
Michael J THOMAS
金额：
$20.9万
依托单位：
WAKE FOREST UNIVERSITY HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
已结题
起止时间：
1998-08-01 至 2001-07-31
来源：
https://reporter.nih.gov/project-details/6044024
关键词：
Cercopithecidae atherosclerotic plaque dietary lipid fatty acid metabolism laboratory rabbit lipid peroxides low density lipoprotein myeloperoxidase nutrition related tag oxidized lipid peroxynitrites saturated fatty acids tyrosine analog unsaturated fatty acids

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英文摘要
DESCRIPTION: The proposed studies will investigate whether fatty acid type and vitamin E concentrations modulate: (1) the amounts of lipid oxidation products isolated from atherosclerotic plaques, and (2) the mechanisms that lead to the formation of lipid oxidation products. NZW rabbits will be maintained on diets enriched in saturated, monounsaturated or n-6 polyunsaturated fat. The diets will contain either high or low concentrations of vitamin E. GC-MS will be used to characterize lipid oxidation products and to infer the mechanisms leading to oxidation assuming that mono-peroxidation products of oleic acid, 3-nitrotyrosine and 3-chlorotyrosine reflect initiation of oxidation by peroxynitrite, free transition metals or Myeloperoxidase, respectively.
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Replacement of GC Mass Spectrometer
Upgrade of mass spectrometer facility
CORE--ANALYTICAL CHEMISTRY LABORATORY
  • 批准号：
    6356488
  • 项目类别：
  • 资助金额：
    $5.34万
  • 财政年份：
    2000
  • 负责人：
    Michael J THOMAS
  • 依托单位：
    WAKE FOREST UNIVERSITY
UPGRADE OF NMR FACILITIES
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